Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Jul 1996
Comparative StudyLate ventricular geometry and performance changes of functional single ventricle throughout staged Fontan reconstruction assessed by magnetic resonance imaging.
We sought to test the hypothesis that late ventricular geometry and performance changes occur in functional single ventricles as they progress through staged Fontan reconstruction. ⋯ No geometric and performance changes from the volume-loaded stage are noted 6 to 9 months after the hemiFontan procedure; however, major changes occur 1 to 2 years after the Fontan procedure. The dramatic changes in the mass/volume ratio seen early after the hemiFontan procedure were not detected at 6 to 9 months. Furthermore diminution of mass, volume and ventricular performance are present at least 2 years after the Fontan procedure.
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J. Am. Coll. Cardiol. · Jul 1996
Myocardial dysfunction after resuscitation from cardiac arrest: an example of global myocardial stunning.
This study investigated the effect of prolonged cardiac arrest and subsequent cardiopulmonary resuscitation on left ventricular systolic and diastolic function. ⋯ Myocardial systolic and diastolic dysfunction is severe after 10 to 15 min of untreated cardiac arrest and successful resuscitation. Full recovery of this postresuscitation myocardial stunning is seen by 48 h in this experimental model of ventricular fibrillation cardiac arrest.
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J. Am. Coll. Cardiol. · Jun 1996
Comparative StudyValidation of three-dimensional echocardiography for quantifying the extent of dyssynergy in canine acute myocardial infarction: comparison with two-dimensional echocardiography.
This study was designed to compare the accuracy of three- and two-dimensional echocardiography for quantifying the extent of abnormal wall motion in experimental acute myocardial infarction, as correlated with the pathologic determination of infarct size. ⋯ Three-dimensional echocardiography is a more accurate means of noninvasively estimating myocardial infarct size in this canine model than two-dimensional echocardiography.
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J. Am. Coll. Cardiol. · May 1996
Randomized Controlled Trial Clinical TrialImprovement of exercise capacity with treatment of Cheyne-Stokes respiration in patients with congestive heart failure.
The aim of this study was to determine the impact of nasal nocturnal oxygen therapy on respiration, sleep, exercise capacity, cognitive function and daytime symptoms in patients with congestive heart failure and Cheyne-Stokes respiration. ⋯ Successful treatment of Cheyne-Stokes respiration with nocturnal nasal oxygen improves not only sleep, but also exercise tolerance and cognitive function in patients with congestive heart failure.
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J. Am. Coll. Cardiol. · May 1996
Randomized Controlled Trial Comparative Study Clinical TrialLate assessment of thrombolytic efficacy (LATE) study: prognosis in patients with non-Q wave myocardial infarction. (LATE Study Investigators)
We examined the impact of thrombolytic therapy and the prognosis of patients with non-Q wave myocardial infarction in a randomized placebo-controlled trial known as the Late Assessment of Thrombolytic Efficacy (LATE) study. ⋯ Patients with non-Q wave myocardial infarction constitute a heterogeneous group of patients. Although the observations presented here are limited by post hoc analysis, it is apparent that patients classified as having a non-Q wave infarction after thrombolytic therapy have a better prognosis than do those given placebo. Late admission of thrombolytic therapy (after 6 h) may also be beneficial in patients presenting with ST depression >2 mm and confirmed myocardial infarction. These hypotheses require prospective testing in a larger number of patients.