Journal of the American College of Cardiology
-
J. Am. Coll. Cardiol. · Nov 1995
Balloon aortic valvuloplasty in adults: failure of procedure to improve long-term survival.
This study sought to determine the long-term outcome of adult patients undergoing percutaneous balloon aortic valvuloplasty. ⋯ Long-term event-free and actuarial survival after balloon aortic valvuloplasty is dismal and resembles the natural history of untreated aortic stenosis. Aortic valve replacement may be performed in selected subjects with good results. However, the prognosis for the remainder of patients who are not candidates for aortic valve replacement is particularly poor.
-
This study reviews the clinical outcome of a series of patients with recurrent pericarditis before and after immunosuppressive therapy. ⋯ The dose and duration of steroid treatment are critical factors in preventing recurrent pericarditis. High dose prednisone with aspirin should be considered in the treatment of recurrent pericarditis resistant to anti-inflammatory therapy. Cyclophosphamide or azathioprine should be reserved for patients who do not respond to high dose prednisone or who experience severe complications related to steroid therapy.
-
J. Am. Coll. Cardiol. · Nov 1995
Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome.
This study used monophasic action potentials to investigate the effects of verapamil and propranolol on epinephrine-induced repolarization abnormalities in congenital long QT syndrome. ⋯ These results indicate that both verapamil and propranolol can improve repolarization abnormalities induced by epinephrine in congenital long QT syndrome.
-
J. Am. Coll. Cardiol. · Oct 1995
Randomized Controlled Trial Multicenter Study Clinical TrialAngioplasty of complex lesions in ischemic rest angina: results of the Thrombolysis and Angioplasty in Unstable Angina (TAUSA) trial.
This study sought to analyze the role of complex lesion morphology on the acute results of angioplasty. ⋯ Complex lesions before coronary angioplasty increase acute complication rates after coronary angioplasty. Urokinase as administered in the TAUSA trial had significant adverse effects, especially in complex lesions. However, even in the placebo arm, complex lesions were associated with higher complication rates than simple lesions. Newer antithrombotic measures that particularly target the platelet may eventually decrease complication rates in these lesions.