Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Jan 2006
Randomized Controlled TrialAtorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure.
This study examined the effect of statin therapy on vascular markers of inflammation and echocardiographic findings in patients with nonischemic forms of cardiomyopathy. ⋯ The use of atorvastatin in patients with nonischemic HF improves LVEF and attenuates adverse LV remodeling. The effects on soluble levels of several inflammatory markers with atorvastatin suggest, in part, mechanisms by which statins might exert their beneficial effects in nonischemic HF.
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J. Am. Coll. Cardiol. · Sep 2005
Randomized Controlled Trial Comparative Study Clinical TrialThe effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: the Losartan Intervention for Endpoint Reduction in hypertension (LIFE) study.
We conducted a subgroup analysis in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study to determine whether aspirin interacted with the properties of losartan, an angiotensin-II receptor antagonist. ⋯ There was a statistical interaction between treatment and aspirin in the LIFE study, with significantly greater reductions for the CEP and MI with losartan in patients using aspirin than in patients not using aspirin at baseline. Further studies are needed to clarify whether this represents a pharmacologic interaction or a selection by aspirin use of patients more likely to respond to losartan treatment.
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J. Am. Coll. Cardiol. · Aug 2005
Letter Randomized Controlled Trial Clinical TrialA randomized trial comparing 1 mg of oral vitamin K with no treatment in the management of warfarin-associated coagulopathy in patients with mechanical heart valves.
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J. Am. Coll. Cardiol. · Aug 2005
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialHigh-volume hemofiltration after out-of-hospital cardiac arrest: a randomized study.
The study examined the effect of isovolumic high-volume hemofiltration (HF) alone or combined with mild hypothermia (HT) on survival after out-of-hospital cardiac arrest (OHCA) with initial ventricular fibrillation or asystole. ⋯ The HF may improve the overall prognosis after resuscitation from OHCA. Combination of HF with mild HT is feasible and should be evaluated in larger trials.
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J. Am. Coll. Cardiol. · Jul 2005
Randomized Controlled Trial Multicenter Study Clinical TrialFunctional status and quality of life after emergency revascularization for cardiogenic shock complicating acute myocardial infarction.
Our goal was to describe the functional status of cardiogenic shock survivors, identify the correlates of cardiogenic shock, and compare global quality of life and functional status of patients randomly assigned to treatment with emergency revascularization (ERV) versus initial medical stabilization (IMS). ⋯ Although one-year mortality after ERV is still high (54%), most survivors have good functional status. The ERV patients have a lower rate of deterioration than IMS patients. The level of recovery for shock patients undergoing ERV is similar to that of historical controls not in cardiogenic shock undergoing elective revascularization.