Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Jul 1994
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialThe Asymptomatic Cardiac Ischemia Pilot (ACIP) study: design of a randomized clinical trial, baseline data and implications for a long-term outcome trial.
The primary objectives of the Asymptomatic Cardiac Ischemia Pilot were 1) to compare the 12-week efficacy of three treatment strategies to suppress cardiac ischemia, and 2) to assess the feasibility of a prognosis trial in patients with asymptomatic cardiac ischemia. ⋯ Design and baseline data for a pilot study of ischemia treatment strategies are described.
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J. Am. Coll. Cardiol. · Jul 1994
Randomized Controlled Trial Comparative Study Clinical TrialActive compression-decompression resuscitation: effect on resuscitation success after in-hospital cardiac arrest.
The purpose of this study was to test the hypothesis that active compression-decompression would improve resuscitation success in human subjects after cardiac arrest. ⋯ Active compression-decompression cardiopulmonary resuscitation improves return of spontaneous circulation and 24-h survival after in-hospital cardiac arrest. Active compression-decompression cardiopulmonary resuscitation appears to be a beneficial adjunct to standard manual cardiopulmonary resuscitation.
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J. Am. Coll. Cardiol. · Jun 1994
Randomized Controlled Trial Clinical TrialEfficacy of spinal cord stimulation as adjuvant therapy for intractable angina pectoris: a prospective, randomized clinical study. Working Group on Neurocardiology.
In a prospective, randomized study with an 8-week follow-up period, we evaluated the efficacy of spinal cord stimulation on exercise capacity and quality of life in patients with intractable angina. ⋯ Spinal cord stimulation significantly improves exercise capacity and quality of life. On the basis of an increase in exercise capacity and rate-pressure product, the mechanism by which spinal cord stimulation acts may be related to improved oxygen supply to the heart combined with an analgesic effect.
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J. Am. Coll. Cardiol. · May 1994
Randomized Controlled Trial Comparative Study Clinical TrialEffect of beta-blockade on heart rate variability in patients with coronary artery disease.
This study assessed the effects of beta-blockade on heart rate variability in patients with coronary artery disease and determined whether the effects of metoprolol in a controlled-release formulation and atenolol differ with regard to electrocardiographic measures of cardiac autonomic control. ⋯ Beta-blockade by metoprolol and atenolol enhance the heart rate variability in patients with coronary artery disease. This may contribute to the protective effects of beta-blockade in ischemic heart disease.
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J. Am. Coll. Cardiol. · Mar 1994
Randomized Controlled Trial Comparative Study Clinical TrialReexamination of the role of endogenous opiates in silent myocardial ischemia.
This study was designed to examine the role of beta-endorphin and met-enkephalin in the pathophysiology of silent myocardial ischemia, with emphasis on their role in the physiologic response to stress. ⋯ Beta-endorphin and met-enkephalin were similar in patients with painful and silent ischemia, and naloxone infusion did not influence anginal symptoms despite effective opiate receptor blockade and a reduction in somatic pain tolerance. These findings suggest that endogenous opiates do not play an important role in modulating symptoms in myocardial ischemia. The increase in beta-endorphin with exercise that coincided with an increase in plasma cortisol is most likely due to its release from the anterior pituitary gland as part of the physiologic stress response.