Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Oct 2009
Review Meta AnalysisIs a pre-operative brain natriuretic peptide or N-terminal pro-B-type natriuretic peptide measurement an independent predictor of adverse cardiovascular outcomes within 30 days of noncardiac surgery? A systematic review and meta-analysis of observational studies.
We conducted a systematic review and meta-analysis to determine if pre-operative brain natriuretic peptide (BNP) (i.e., BNP or N-terminal pro-B-type natriuretic peptide [NT-proBNP]) is an independent predictor of 30-day adverse cardiovascular outcomes after noncardiac surgery. ⋯ These results suggest that an elevated pre-operative BNP or NT-proBNP measurement is a powerful, independent predictor of cardiovascular events in the first 30 days after noncardiac surgery.
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J. Am. Coll. Cardiol. · Jan 2009
Meta AnalysisMeta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk.
To determine the relationship between non-high-density lipoprotein cholesterol (HDL-C) lowering and coronary heart disease (CHD) risk reduction for various lipid-modifying therapies. ⋯ Non-HDL-C is an important target of therapy for CHD prevention. Most lipid-modifying drugs used as monotherapy have an approximately 1:1 relationship between percent non-HDL-C lowering and CHD reduction.
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J. Am. Coll. Cardiol. · Oct 2008
Meta AnalysisRelation of beta-blocker-induced heart rate lowering and cardioprotection in hypertension.
The purpose of this study was to evaluate the role of heart rate reduction with beta-blockers on the risk of cardiovascular events in patients with hypertension. ⋯ In contrast to patients with myocardial infarction and heart failure, beta-blocker-associated reduction in heart rate increased the risk of cardiovascular events and death for hypertensive patients.
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J. Am. Coll. Cardiol. · Feb 2008
Meta AnalysisAntiarrhythmic effect of statin therapy and atrial fibrillation a meta-analysis of randomized controlled trials.
To improve the evaluation of the possible antiarrhythmic effect of statins, we performed a meta-analysis of randomized trials with statins on the end point of incidence or recurrence of atrial fibrillation (AF). ⋯ Use of statins was significantly associated with a decreased risk of incidence or recurrence of AF in patients in sinus rhythm with a history of previous AF or undergoing cardiac surgery or after acute coronary syndrome.