Journal of hypertension
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Journal of hypertension · Jul 2003
Geographic variations in the prevalence, awareness, treatment and control of hypertension in China.
To compare the prevalence, awareness, treatment and control of hypertension in north and south, and urban and rural residents of China. ⋯ Our study documents a marked north-south gradient in the prevalence of hypertension in China. The previously reported urban-rural difference in the prevalence of hypertension was not noted, perhaps due to a rapid increase in the prevalence of hypertension in rural China.
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Journal of hypertension · Jun 2003
Meta AnalysisCardiovascular prevention and blood pressure reduction: a quantitative overview updated until 1 March 2003.
In a meta-analysis published in October 2001, we reported that new and old classes of antihypertensive drugs had similar long-term efficacy and safety. Furthermore, we observed that in clinical trials in hypertensive or high-risk patients gradients in systolic pressure accounted for most differences in outcome. ⋯ The hypothesis that new antihypertensive drugs, such as calcium-channel blockers, alpha-blockers, ACE inhibitors or AR1 blockers might influence cardiovascular prognosis over and beyond their antihypertensive effects remains unproven. The finding that blood pressure differences largely accounted for cardiovascular outcome emphasizes the desirability of tight blood pressure control. However, the level to which blood pressure must be lowered to achieve maximal benefit remains currently unknown.
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Journal of hypertension · May 2003
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialThe Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial.
The prognostic benefits of blood pressure lowering treatment in elderly hypertensive patients were established more than a decade ago, but are less clear in those with mildly to moderately elevated blood pressure. ⋯ In elderly hypertensive patients, a slightly more effective blood pressure reduction during candesartan-based therapy, compared with control therapy, was associated with a modest, statistically non-significant, reduction in major cardiovascular events and with a marked reduction in non-fatal stroke. Cognitive function was well maintained in both treatment groups in the presence of substantial blood pressure reductions. Both treatment regimens were generally well tolerated.
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Journal of hypertension · Jan 2003
Removing confounders from the relationship between mortality risk and systolic blood pressure at low and moderately increased systolic blood pressure.
To assess the relationship between mortality risk and systolic blood pressure (SBP) at low and moderately increased SBP (less than the 70th percentile) before and after correcting for the regression-dilution bias and J-curve effects. ⋯ These two corrections transformed the relationship between mortality risk and SBP at low and moderately increased SBP from no association to a robustly positive association starting at 120 mmHg, for the majority of individuals.