Journal of hypertension
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Journal of hypertension · May 2002
Randomized Controlled Trial Clinical TrialLow-dose aspirin does not interfere with the blood pressure-lowering effects of antihypertensive therapy.
It has been reported that aspirin (ASA) may interfere with the blood pressure (BP)-lowering effect of various antihypertensive agents and attenuate the beneficial effects of angiotensin-converting enzyme (ACE) inhibitors in patients with congestive heart failure. ⋯ Even long-term, low-dose ASA does not interfere with the BP-lowering effect of antihypertensive agents, including combinations with ACE inhibitors, or with renal function. No negative interaction occurs between ACE inhibition and the cardiovascular benefits of small dose of ASA. Our conclusions cannot be extended to larger doses of ASA, or to patients with congestive heart failure.
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Journal of hypertension · Nov 1999
Randomized Controlled Trial Clinical TrialPROGRESS - Perindopril Protection Against Recurrent Stroke Study: characteristics of the study population at baseline. Progress Management Committee.
The primary aim of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) is to determine the effects of a long-term angiotensin converting enzyme (ACE)-inhibitor-based blood-pressure-lowering regimen on the risk of stroke among patients with a history of stroke or transient ischaemic attack (TIA). Secondary aims include investigation of the effects of treatment on total cardiovascular events, dementia and disability. ⋯ The successful completion of recruitment, together with current indicators of statistical power, suggest that PROGRESS should achieve its primary aim on schedule.
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Journal of hypertension · Aug 1999
Randomized Controlled Trial Clinical TrialEvaluation of the potential interaction between NaCl and prostaglandin inhibition in elderly individuals with isolated systolic hypertension.
To evaluate whether prostaglandin inhibition with the non-steroidal anti-inflammatory drug (NSAID), indomethacin (I) interacts synergistically with different doses of salt (NaCl) in elevating systolic blood pressure (SBP). ⋯ Chronic high salt diet elevated blood pressure more than I in the total cohort of elderly individuals. No interaction was demonstrated and their effects were additive. In the ISH group, chronic high salt diet significantly increased SBP and DBP while I failed to alter blood pressure. In the normotensive group, I, but not salt, elevated SBP. Patients with ISH are sensitive to the pressor effect of NaCl but resistant to the pressor effect of prostaglandin inhibition in contrast to elderly normotensive control individuals where the reverse was found.
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Journal of hypertension · Mar 1998
Randomized Controlled Trial Clinical TrialA study of the interactive effects of oral contraceptive use and dietary fat intake on blood pressure, cardiovascular reactivity and glucose tolerance in normotensive women.
To investigate the interactive effects of oral contraceptive pill use and dietary fat intake on cardiovascular haemodynamics and metabolic parameters in young normotensive women. ⋯ These results confirm that oral contraceptive pills have the potential to cause adverse effects on blood pressure, cardiovascular reactivity and the insulin-production response to administration of glucose and suggest that some of the beneficial effects of a low-fat diet on these parameters may be negated in women taking oral contraceptive pills.
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Journal of hypertension · Dec 1995
Randomized Controlled Trial Clinical TrialQuantitative analysis of retinal vascular changes in essential and renovascular hypertension.
To describe a quantitative analysis method for retinal vascular changes and to study retinal vascular changes in patients with mild essential or renovascular hypertension in relation to 24-h ambulatory blood pressure monitoring. ⋯ Our quantitative retinal vascular analysis method detected an increased vascular diameter in both essential and renovascular hypertensives, which was related to night-time blood pressure and, in particular, to an attenuated nocturnal blood pressure decline. Vascular rarefaction in essential hypertension was not related to blood pressure and could influence the pathogenesis of essential hypertension.