Journal of neuro-oncology
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Journal of neuro-oncology · Mar 2021
Genomic alterations predictive of response to radiosurgery in recurrent IDH-WT glioblastoma.
Despite aggressive treatment, glioblastoma invariably recurs. The optimal treatment for recurrent glioblastoma (rGBM) is not well defined. Stereotactic radiosurgery (SRS) for rGBM has demonstrated favorable outcomes for selected patients; however, its efficacy in molecular GBM subtypes is unknown. We sought to identify genetic alterations that predict response/outcomes from SRS in rGBM-IDH-wild-type (IDH-WT). ⋯ SRS is a safe and effective treatment option for selected rGBM-IDH-WT patients following first recurrence. rGBM-IDH-WT harboring PTEN-mutation have improved survival with salvage SRS compared to PTEN-WT patients. PTEN may be used as a molecular biomarker to identify a subset of rGBM patients who may benefit the most from SRS.
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Journal of neuro-oncology · Dec 2021
Stereotactic radiosurgery for IDH wild type glioblastoma: an international, multicenter study.
Isocitrate dehydrogenase (IDH) mutation status is recommended used for diagnosis and prognostication of glioblastoma patients. We studied efficacy and safety of stereotactic radiosurgery (SRS) for patients with recurrent IDH-wt glioblastoma. ⋯ SRS prescription dose of > 14 Gy is associated with longer progression free survival while tumor volume of > 5 cc is associated with shorter overall survival after SRS for IDH-wt glioblastomas. AREs are rare and are typically managed conservatively.
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Journal of neuro-oncology · Jan 2020
Impact of brain metastasis velocity on neurologic death for brain metastasis patients experiencing distant brain failure after initial stereotactic radiosurgery.
Patients with high rates of developing new brain metastases have an increased likelihood of dying of neurologic death. It is unclear, however, whether this risk is affected by treatment choice following failure of primary stereotactic radiosurgery (SRS). ⋯ Intermediate and high risk BMV groups are predictive of neurologic death. The association between BMV and neurologic death remains strong for patients treated within the immunotherapy era.
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Journal of neuro-oncology · Nov 2019
Observational StudyWHO grade of intracranial meningiomas differs with respect to patient's age, location, tumor size and peritumoral edema.
To analyse whether the WHO grade of intracranial meningiomas differs itself depending on patients and meningioma characteristics at diagnosis. ⋯ In this series atypical meningioma was associated with younger age, location on the convexity, larger tumor size and more peritumoral edema.
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Journal of neuro-oncology · Dec 2015
Review GuidelineThe role of surgery in the management of patients with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Should patients with imaging suggestive of low grade glioma (LGG) undergo observation versus treatment involving a surgical procedure? ⋯ Intraoperative mapping is recommended for patients with diffuse LGGs in eloquent locations compared to patients with non-eloquently located diffuse LGGs as a way of preserving function.