Resuscitation
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To examine interventions and timing of emergency team calls in hospitals with or without a medical emergency team (MET). ⋯ Nearly all emergency team calls required critical care type interventions. Emergency team calls show a unique temporal pattern for both MET and control hospitals. These findings have important organizational and resource-related implications for hospitals evaluating and establishing rapid response systems.
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Comparative Study
Out-of-hospital cardiac arrest in patients aged 35 years and under: a 4-year study of frequency and survival in London.
The aim of this study was to describe the frequency and characteristics of cardiac arrest patients of 35 years and under attended by the London Ambulance Service NHS Trust between April 2003 and March 2007. Few large studies have described the occurrence, mechanism, resuscitation viability and outcome of this substantial subset of the cardiac arrest population. By documenting over 3000 cardiac arrests in young people we sought to improve understanding, awareness and ultimately survival of a condition notorious for high mortality rates. ⋯ Mortality in young cardiac arrest patients remains high. Focus should be placed on tackling social and psychological causes of cardiac arrest as well as cardiac aetiologies.
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Comparative Study
The impact of Rapid Response System on delayed emergency team activation patient characteristics and outcomes--a follow-up study.
To evaluate the impact of Rapid Response System (RRS) maturation on delayed Medical Emergency Team (MET) activation and patient characteristics and outcomes. ⋯ Maturation of a RRS is associated with a decrease in the incidence of unplanned ICU admissions and MET activation delay. Assessment of a RRS early in the course of its implementation may underestimate its efficacy.
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Naloxone's use in cardiac arrest has been of recent interest, stimulated by conflicting results in both human case reports and animal studies demonstrating antiarrhythmic and positive ionotropic effects. We hypothesized that naloxone administration during cardiac arrest, in suspected opioid overdosed patients, is associated with a change in cardiac rhythm. ⋯ Although we cannot support the routine use of naloxone during cardiac arrest, we recommend its administration with any suspicion of opioid use. Due to low rates of return of spontaneous circulation and survival during cardiac arrest, any potential intervention leading to rhythm improvement is a reasonable treatment modality.
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The use of emergency cardiopulmonary bypass (ECPB) resuscitation after cardiac arrest may offer hope for survival when standard ACLS therapies fail. However, whether cooling adds benefit to ECPB is unknown and we lack an ECPB rodent model for experimental studies. We sought to (a) develop a 72 h survival rodent model using ECPB to treat asphyxial cardiac arrest and (b) use this new model to evaluate early mild and moderate hypothermia versus normothermia during ECPB resuscitation. ⋯ A rodent model of ECPB is feasible and useful for resuscitation studies. The addition of early mild and moderate hypothermia to ECPB resuscitation significantly improves survival compared with normothermic ECPB in rats.