Resuscitation
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Therapeutic hypothermia (HT) is the standard treatment after perinatal hypoxic-ischemic (HI) injury. Infection increases vulnerability to HI injury, but the effect of HT on lipopolysaccharide (LPS) sensitized HI brain injury is unknown. ⋯ Therapeutic hypothermia is not neuroprotective in this LPS-sensitized unilateral stroke-like HI brain injury model in newborn rats. Lack of neuroprotection was particularly seen in the hippocampus. Pre-insult exposure to LPS also induced brain area loss in the unligated hemisphere, which is normally not affected in this model.
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Editorial Comment
Characterising early recovery in survivors of cardiac arrest.
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Editorial Comment
Patients' resuscitation preferences in context: Lessons from POLST.
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Letter Case Reports
Total recall-Is it ethical not to sedate people during successful resuscitation?