Resuscitation
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Multiple organ dysfunction resulting from hemorrhagic shock (HS) and subsequent resuscitation was mediated by several inflammatory factors such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10). The present study was designed to investigate the protective effects of fluvastatin on these mediators after HS in rats. ⋯ Pre-treatment with fluvastatin can suppress the release of serum TNF-alpha and can also increase serum IL-10 level to protect HS-induced multi-organ damage in rats.
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Multicenter Study Clinical Trial
Chest compression quality variables influencing the temporal development of ROSC-predictors calculated from the ECG during VF.
Predictive measures that reflect the probability of return of spontaneous circulation (ROSC) if the patient is defibrillated can be calculated from the electrocardiogram during ventricular fibrillation (VF) and ventricular tachycardia (VT). It has not been studied how the quality of chest compressions affect the development of such ROSC predictors. ⋯ Using MS as an indicator of the state of the myocardium, force-based compression quality variables are better indicators of efficient CPR than compression depth. A novel indicator termed residual heart force gives the best correlation with observed trends in MS.
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Patients who survive after suicidal hanging attempts suffer from transient brain ischaemia. Morbidity and mortality is high, and no specific therapy is available. Hypothermia attenuates ischaemic brain damage and has become standard care in comatose survivors of cardiac arrest; therapeutic hypothermia may thus be useful for near-hanging victims as well. ⋯ No randomised, controlled trial for treatment of near-hanging victims has been published. No conclusions could be drawn regarding treatment effects of hypothermia in this survey, but in the absence of better evidence, it seems reasonable to consider hypothermia treatment in all comatose near-hanging victims.