Resuscitation
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Randomized Controlled Trial
Repetitive versus standard tactile stimulation of preterm infants at birth - A randomized controlled trial.
To evaluate the direct effect of repetitive tactile stimulation on breathing effort of preterm infants at birth. ⋯ Although the increase in respiratory effort during repetitive stimulation did not reach significance, oxygenation significantly improved with a lower level of FiO2 at transport to the NICU. Repetitive tactile stimulation could be of added value to improve breathing effort at birth.
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Randomized Controlled Trial
Time to awakening after cardiac arrest and the association with target temperature management.
Target temperature management (TTM) at 32-36 °C is recommended in unconscious survivors of cardiac arrest. This study reports awakening in the TTM-trial. Our predefined hypotheses were that time until awakening correlates with long-term neurological outcome and is not affected by level of TTM. ⋯ Late awakening is common and often has a good neurological outcome. Time to awakening was longer in TTM33 than in TTM36, this difference could not be attributed to differences in sedative drugs administered during the first 48 h.
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Randomized Controlled Trial
24 vs. 72 hours of hypothermia for pediatric cardiac arrest: A pilot, randomized controlled trial.
Children surviving cardiac arrest (CA) lack proven neuroprotective therapies. The role of biomarkers in assessing response to interventions is unknown. We hypothesized that 72 versus 24 h of hypothermia (HT) would produce more favorable biomarker profiles after pediatric CA. ⋯ Serum biomarkers show promise as theragnostic tools in pediatric CA. Our biomarker and safety data also suggest that 72 h duration after pediatric CA warrants additional exploration.
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Randomized Controlled Trial
Self-learning basic life support: A randomised controlled trial on learning conditions.
To investigate whether pure self-learning without instructor support, resulted in the same BLS-competencies as facilitator-led learning, when using the same commercially available video BLS teaching kit. ⋯ Self-learning is not inferior to facilitator-led learning in the short term. Self-learning resulted in a better retention of BLS-skills three months after training compared to facilitator-led training.
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Randomized Controlled Trial Multicenter Study
Paediatric in-hospital cardiac arrest: Factors associated with survival and neurobehavioural outcome one year later.
To investigate clinical characteristics associated with 12-month survival and neurobehavioural function among children recruited to the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital trial. ⋯ Cardiac arrest and resuscitation factors are associated with long-term survival and neurobehavioural function among children who are comatose after in-hospital arrest.