International journal of psychophysiology : official journal of the International Organization of Psychophysiology
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Int J Psychophysiol · Feb 2009
Randomized Controlled Trial Clinical TrialEnd-tidal versus transcutaneous measurement of PCO2 during voluntary hypo- and hyperventilation.
Recent studies have shown that end-tidal PCO(2) is lower during anxiety and stress, and that changing PCO(2) by altering breathing is therapeutic in panic disorder. However, end-tidal estimation of arterial PCO(2) has drawbacks that might be avoided by the transcutaneous measurement method. Here we compare transcutaneous and end-tidal PCO(2) under different breathing conditions in order to evaluate these methods in terms of their comparability and usability. ⋯ The results show that PCO(2) estimated by the two methods was comparable except that for transcutaneous measurement registration of changes in PCO(2) was delayed and absolute levels were much higher. Both methods documented that paused breathing was effective for raising PCO(2), a presumed antidote for anxious hyperventilation. We conclude that since the two methods give comparable results choosing between them for specific applications is principally a matter of whether the time lag of the transcutaneous method is acceptable.
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Int J Psychophysiol · Aug 2008
Randomized Controlled TrialEffects of opioid blockade on nociceptive flexion reflex thresholds and nociceptive responding in hypertensive and normotensive individuals.
Hypertension and risk for hypertension have been associated with reduced pain sensitivity. It has been hypothesised that endogenous opioids contribute to this hypertensive hypoalgesia. ⋯ Neither nociceptive flexion reflex thresholds nor nociceptive responding differed between hypertensives and normotensives during placebo or naltrexone. These data provide no support for the hypothesis that essential hypertension is characterised by higher levels of endogenous opioids in the central nervous system and reveal no association between blood pressure status and nociceptive flexion reflex responses.
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Int J Psychophysiol · Jul 2008
Randomized Controlled Trial Controlled Clinical TrialTaxometric analysis of biceps femoris EMG following electrocutaneous stimulation over the sural nerve: determining the latent structure of the nociceptive flexion reflex (NFR).
The nociceptive flexion reflex (NFR) is a polysynaptic withdrawal reflex typically assessed from biceps femoris electromyogram (EMG) following noxious stimulation of the ipsilateral sural nerve. Electrophysiological evidence suggests the reflex is elicited following the activation of small diameter A-delta afferents. As a result, the NFR is assumed to be a categorically distinct construct that emerges from EMG activity only following nociceptor activation. ⋯ Results suggested the presence of a taxon in the covariance of biceps femoris EMG and stimulus intensity that is likely to be the NFR. Furthermore, preliminary analyses suggested the best method of scoring NFR magnitude was using Cohen's d. Implications of these results are discussed.
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Int J Psychophysiol · Apr 2004
Randomized Controlled Trial Clinical TrialFocused analgesia and generalized relaxation produce differential hypnotic analgesia in response to ascending stimulus intensity.
This study was designed in order to examine the effects of different types of hypnotic suggestion on hypnotic analgesia. Generalized relaxation and focused analgesia were induced in seven high-hypnotizable (HH) and eight low-hypnotizable (LH) subjects. Subjects were not aware to which group they belonged. ⋯ We conclude that by utilizing two modes of hypnotic suggestions in response to ascending stimuli, we were able to discover two components of hypnotic analgesia. One shows a parallel shift in the stimulus-response function, has features similar to placebo and bears no clear relationship to hypnotic susceptibility. The other shows a slope change in the stimulus-response curve and has a positive relationship to hypnotic susceptibility.
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Int J Psychophysiol · Jan 1992
Randomized Controlled Trial Clinical TrialStimulus rise time, intensity and the elicitation of unconditioned cardiac and electrodermal responses.
In recent discussions on the differentiation of orienting, startle and defense responses, the importance of stimulus rise time for the elicitation of different cardiac response patterns was re-emphasized. Especially, it has been claimed that phasic accelerative heart rate (HR) responses-interpreted as indicators of startle-might not only be evoked by auditory stimuli with instantaneous rise times and high intensities, but also by low to moderate stimulus intensities with sudden onsets. The present study examined this question by manipulating rise time (instantaneous vs. 50 ms) and intensity (60 vs. 95 dB). ⋯ As a consequence of stimulus change, larger SCRs as well as larger decelerative HR responses were observed without, however, being affected by the direction of the change in rise time. In sum, the present study suggests that the role attributed to rise time with respect to eliciting qualitatively different cardiac response patterns has been exaggerated. The consequences for the differentiation of different unconditioned responses are briefly addressed.