European journal of anaesthesiology
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Letter Case Reports
Peripheral Tapia's syndrome after cardiac surgery.
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Randomized Controlled Trial Comparative Study
Comparative evaluation of propofol 350 and 200 mg for induction of anaesthesia in morbidly obese patients: a randomized double-blind pilot study.
The aim of this pilot study was to evaluate efficacy and safety of propofol 350 versus 200 mg for induction of anaesthesia in morbidly obese patients undergoing bariatric surgery. ⋯ Although propofol 200 mg proved to be an inadequate induction dose for morbidly obese patients, the 350 mg induction dose deserves further study, provided the maintenance dose is not started within 5 min, thereby preventing temporary cardiovascular instability.
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Comparative Study
Positive end-expiratory pressure improves end-expiratory lung volume but not oxygenation after induction of anaesthesia.
Induction of anaesthesia promotes collapse of dependent lung regions in both obese and nonobese patients. We hypothesized that end-expiratory lung volume (EELV) may be more sensitive than oxygenation to evaluate the effects of positive end-expiratory pressure (PEEP) after anaesthesia induction. ⋯ After induction of anaesthesia, mechanical ventilation with ZEEP is associated with a profound reduction in EELV. PEEP improves efficiently EELV and respiratory mechanics, with no major effect on oxygenation. EELV may be a useful indicator to guide PEEP setting in the operating room.
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Randomized Controlled Trial Comparative Study
Study of the systemic and pulmonary oxidative stress status during exposure to propofol and sevoflurane anaesthesia during thoracic surgery.
General anaesthesia during mechanical ventilation can induce variable systemic and pulmonary immune effects that may affect postoperative outcome. The aim of the present study was to evaluate evidence of oxidative stress in the blood and bronchoalveolar lavage (BAL) fluid of patients exposed to propofol or sevoflurane anaesthesia during thoracic surgery. ⋯ Sevoflurane seemed to induce a local and systemic oxidative stress, whereas propofol is more likely to have antioxidant properties. Sevoflurane appears to cause a greater intrapulmonary proinflammatory response than propofol during thoracic surgery.