European journal of anaesthesiology
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Randomized Controlled Trial Multicenter Study Comparative Study
Kinetics of plasma biomarkers of inflammation and lung injury in surgical patients with or without postoperative pulmonary complications.
Postoperative pulmonary complications (PPCs) are common after major abdominal surgery. The kinetics of plasma biomarkers could improve identification of patients developing PPCs, but the kinetics may depend on intraoperative ventilator settings. ⋯ In patients undergoing abdominal surgery and at risk of developing PPCs, plasma levels of biomarkers for inflammation or lung injury showed distinct kinetics with development of PPCs, but none of the biomarkers showed sufficient prognostic value. The use of high levels of PEEP was associated with increased levels of CC-16, suggesting lung overdistension.
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Multicenter Study Observational Study
A survey of the dose of inhalational agents used to maintain anaesthesia in infants.
Various animal studies suggest that currently used anaesthetics are toxic to the developing brain. Many reviews advise that the total anaesthetic drug exposure should be reduced but the dose usually used in clinical practice has not been clearly elucidated. ⋯ The concentration of inhalational anaesthetics in %MAC increased with age and was lowest in neonates. Most young infants received inhalational anaesthetics at a concentration below 1 MAC, which accords with current guidance to minimise anaesthetic drug exposure but may have unintended consequences.
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Multicenter Study Observational Study
External validation of predictive models for acute kidney injury following cardiac surgery: A prospective multicentre cohort study.
Four predictive models for acute kidney injury associated with cardiac surgery were developed by Demirjian in the United States in 2012. However, the usefulness of these models in clinical practice needs to be established in different populations independent of that used to develop the models. ⋯ Overall, the lack of calibration of these models and the difficulty in using the models clinically because of the large number of variables limit their applicability.
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Multicenter Study Observational Study
Implementation of patient blood management remains extremely variable in Europe and Canada: The NATA benchmark project.
Preoperative anaemia is associated with increased postoperative morbidity and mortality. Patient blood management (PBM) is advocated to improve patient outcomes. ⋯ Implementation of PBM remains extremely variable across centres. The relative importance of factors explaining RBC transfusion differs across institutions, some being patient related whereas others are related to the healthcare process. The results reported confidentially to each centre will allow them to implement tailored measures to improve their PBM strategies.
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Multicenter Study Comparative Study Observational Study
Determination of loss of consciousness: a comparison of clinical assessment, bispectral index and electroencephalogram: An observational study.
Computer-processed algorithms of encephalographic signals are widely used to assess the depth of anaesthesia. However, data indicate that the bispectral index (BIS), a processed electroencephalography monitoring system, may not be reliable for assessing the depth of anaesthesia. ⋯ This trial was not registered because registration was not mandatory at the time of the trial.