European journal of anaesthesiology
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Randomized Controlled Trial
Prophylactic fibrinogen concentrate administration in surgical correction of paediatric craniosynostosis: A double-blind placebo-controlled trial.
Surgical craniosynostosis repair in children is associated with massive blood loss and significant transfusion of blood products. Fibrinogen concentrate is claimed to be useful in reducing blood loss and transfusion requirements. ⋯ During surgical craniosynostosis repair in young children, prophylactic administration of high-dose fibrinogen concentrate did not reduce the amount of transfused blood products or decrease peri-operative blood loss.
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Randomized Controlled Trial
Does a balanced colloid decrease perioperative blood loss in paediatric cardiac surgery: A double-blinded randomized controlled trial?
Unbalanced fluid solutions cause metabolic acidosis and could be associated with impaired coagulation and increased blood loss. ⋯ The use of a balanced colloid for peri-operative fluid therapy compared with a saline one is not associated with decreased blood loss or exposure to blood products.
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Randomized Controlled Trial
Physostigmine for prevention of postoperative delirium and long-term cognitive dysfunction in liver surgery: A double-blinded randomised controlled trial.
Anecdotally, cholinergic stimulation has been used to treat delirium and reduce cognitive dysfunction. ⋯ Physostigmine had no effect on POD and POCD when applied after induction of anaesthesia up to 24 h.
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Randomized Controlled Trial
No interactive effect of lumbar epidural blockade and target-controlled infusion of propofol on mean arterial pressure, cardiac output and bispectral index: A randomised controlled and pharmacodynamic modelling study.
It is generally accepted that a neuraxial blockade strengthens the sedative effects of propofol. Deafferentation caused by neuraxial blockade is thought to play a key role. ⋯ Epidural blockade reduces the propofol requirements for sedative end points. This is not the result of a pharmacodynamic interaction.
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Randomized Controlled Trial Multicenter Study
Reducing the time to successful intravenous cannulation in anaesthetised children with poor vein visibility using a near-infrared device: A randomised multicentre trial.
During inhalational induction of anaesthesia for children, severe respiratory events can occur but can be rapidly treated once intravenous access is in place. Reducing the time to successful cannulation during inhalational induction for children with poor vein visibility would improve safety. ⋯ NCT01685866 (http://www.clinicaltrials.gov).