European journal of anaesthesiology
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Randomized Controlled Trial Clinical Trial
Bispectral index monitoring in patients undergoing cardiac surgery under cardiopulmonary bypass.
Monitoring the depth of anaesthesia by the bispectral index facilitates the titration of anaesthetic drugs during operation as well as assisting in early recovery. We planned to use this index to control the administration of anaesthetic agents in order to stabilize haemodynamics and promote recovery from anaesthesia in patients undergoing cardiac surgery with cardiopulmonary bypass. ⋯ Anaesthesia controlled by bispectral index monitoring decreases the incidence of haemodynamic disturbances and facilitates titration of anaesthetic agents during cardiopulmonary bypass and thus may assist recovery from anaesthesia.
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Randomized Controlled Trial Comparative Study Clinical Trial
Preoperative oral celecoxib versus preoperative oral rofecoxib for pain relief after thyroid surgery.
The study compared the analgesic efficacy and safety of two preoperatively administered cyclo-oxygenase-2 inhibitors, celecoxib and rofecoxib. ⋯ The preoperative administration of rofecoxib 50 mg and less so of celecoxib 200 mg provide a significant analgesic benefit with regard to postoperative pain relief and decrease in additional opioid requirements after thyroid surgery.
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Randomized Controlled Trial Comparative Study Clinical Trial
Propofol versus remifentanil for monitored anaesthesia care during colonoscopy.
We conducted an open, prospective, randomized study to compare the efficacy, safety and recovery characteristics of remifentanil or propofol during monitored anaesthesia care in patients undergoing colonoscopy. ⋯ Remifentanil proved efficient in reducing pain during colonoscopy. Emergence times were shorter and the recovery of cognitive function was faster with remifentanil compared with propofol. Remifentanil provided a smoother haemodynamic profile than propofol; however, the frequent occurrence of remifentanil-induced hypoventilation requires the cautious administration of this agent.
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Randomized Controlled Trial Comparative Study Clinical Trial
Oral premedication with fentanyl may be a safe and effective alternative to oral midazolam.
Although midazolam is commonly given orally to infants and small children for premedication, the taste is sometimes unacceptable even when mixed with syrup. We tested the efficacy and safety of oral fentanyl compared with oral midazolam in a randomized open-label study. ⋯ Oral administration of fentanyl 30 min before entrance to the holding room for an operation from a bottle with a small orifice is a premedication option for children between 1 and 8 yr of age.
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Randomized Controlled Trial Comparative Study Clinical Trial
Pain on injection of propofol: comparison of metoprolol with lidocaine.
Pain is often experienced when propofol is injected, and intravenous lidocaine is often effective in preventing such pain. We decided to determine whether metoprolol, given before the injection of propofol, is as effective as lidocaine in reducing the incidence and severity of the pain. ⋯ Pretreatment with intravenous metoprolol was equally as effective as lidocaine in reducing the pain associated with propofol injection.