European journal of anaesthesiology
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Randomized Controlled Trial Comparative Study Clinical Trial
Effects of different glucose concentrations on spinal anaesthesia with bupivacaine and tetracaine.
The effects of 5% and 8% glucose in 0.5% tetracaine or bupivacaine on the anaesthetic spread were investigated in 80 urological patients requiring spinal anaesthesia for trans-urethral resection of the prostate. The local anaesthetic solutions were randomly administered, the patients being divided into four groups of 20, and the anaesthetic profile was then evaluated in a double-blind fashion by an independent observer. Maximum cephalad spread of analgesia was significantly greater with tetracaine in 8% glucose compared to the other three groups (tetracaine/5% glucose, bupivacaine/5 or 8% glucose) (P less than 0.05). ⋯ Both the 5% and 8% solutions of tetracaine achieved a 3+ motor blockade significantly faster than either bupivacaine solution. Regression of motor blockade from tetracaine was not influenced by the glucose concentration, but the 8% solution of bupivacaine had a delayed 2+ and 3+ blockade, although the ultimate decay for both solutions was similar. The results of our study suggest that 0.5% bupivacaine 4 ml in 5% glucose provides a rapid and controllable spread of sensory analgesia for transurethral surgery, of optimal duration associated with a complete motor blockade of moderate duration.
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A new way of saving anaesthetic vapours is described. The method is analogous to the heat-moisture exchanger principle: the vapour is trapped in a filter during expiration and is returned to the patient during the subsequent inspiration. ⋯ In model lung tests, this reduced the isoflurane consumption by 51% at a tidal volume of 300 ml, by 57% at 600 ml and by 51% at 930 ml. Neither isoflurane nor halothane yielded any degradation products when brought in contact with the zeolite.
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Comparative Study
Outcome from intensive care. I. A 5-year study of 1308 patients: methodology and patient population.
During a 5-year period, from 1979 to 1983, demographic and disease-related data were collected prospectively on 1308 adult patients from 1555 admissions to a multidisciplinary intensive care unit (ICU) in a Danish university hospital. The patients were followed during the stay in ICU, the ensuing hospital stay, and up to 8 years after discharge from hospital. The male: female ratio was 1:1. ⋯ The APACHE- and TISS-systems were simultaneously applied to a representative sample of 216 consecutive admissions. The average APACHE score was 14.9 +/- 8.2 and the average TISS score 28.3 +/- 11.1 points. The ICU patients presented in this paper do not differ much from ICU patients in other outcome studies.
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Comparative Study Clinical Trial Controlled Clinical Trial
Suxamethonium-induced facilitation of spontaneous frontal EMG activity.
The behaviour of spontaneous frontal electromyographic activity (FEMG) was studied during the recovery from suxamethonium and vecuronium block. In order to obtain comparable conditions in the study groups, the duration of the suxamethonium block was prolonged with a suxamethonium infusion. The FEMG was continuously recorded and the evoked electromyographic (EEMG) and twitch tension (ETT) responses were measured every 10 s from the thenar muscles. ⋯ In the suxamethonium group there was an increase in FEMG in all six patients when EEMG had recovered to 10%, and significantly higher FEMG readings were obtained during further recovery from the block. Thus, early recovery of neuromuscular transmission is detected by FEMG more easily when suxamethonium is used instead of vecuronium. The different behaviour of FEMG may reflect a difference in the recovery ratio of ETT/EEMG or in the anaesthetic depth caused by the two types of neuromuscular blockers.
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Randomized Controlled Trial Clinical Trial
Post-operative sore throat: effect of lignocaine jelly and spray with endotracheal intubation.
The effects of laryngeal lignocaine spray and/or lignocaine jelly as lubricants were studied on the incidence of sore throat, hoarseness, or tracheal irritability as evidenced by either a tendency to cough or frank coughing after intubation with a Sensiv tube (Searle Medical Products). Pressure in the medium-volume, low-pressure cuff was controlled and kept below 2.5 kPa (25 cmH2O) during anaesthesia. The side-effects of 94 surgical patients were recorded in a double-blind manner in the recovery room and on the first post-operative day. ⋯ In 42% of the patients receiving N2O a limiting value of 2.5 kPa (25 cmH2O) was reached during anesthesia in a mean time of 74 min (range 25-180 min). After the replacement of N2O with nitrogen, the cuff pressure decreased from 1.8 kPa (18 cmH2O) to 0.7 kPa (7 cmH2O) over 40 min. It is concluded that lignocaine jelly with the use of a spray significantly increases post-operative side-effects.