Anaesthesia and intensive care
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Anaesth Intensive Care · Sep 2014
An audit of the statistical validity of conclusions of clinical superiority in anaesthesia journals.
Making a statistically valid conclusion of the superiority of a clinical intervention in a clinical trial requires not only a statistically significant P value, but also adequate a priori power and an observed effect size larger than the clinically important value specified in the sample size calculation. We scrutinised the five most highly cited clinical trials reporting one or more conclusions of clinical superiority published in Anesthesiology, the British Journal of Anaesthesia, Anaesthesia, Anesthesia and Analgesia and Anaesthesia and Intensive Care in 2011 or 2012 to determine how many met all three requisite criteria. In the 25 articles, there were a total of 36 unconditional conclusions of the superiority of a clinical intervention. ⋯ The remainder included secondary outcomes without specific reference to their observational nature, and primary outcomes whose observed effect size was smaller than the clinically important value specified in the sample size calculation. These findings indicate that clinicians should closely scrutinise conclusions of clinical superiority in anaesthesia journals. Many will be 'hypothesis-generating observations' without adequate statistical support for a conclusion of clinical superiority in their own right.
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Anaesth Intensive Care · Sep 2014
ReviewCosts and consequences: a review of discharge opioid prescribing for ongoing management of acute pain.
Over recent years there has been a growing need for patients to be sent home from hospital with prescribed opioids for ongoing management of their acute pain. Increasingly complex surgery is being performed on a day-stay or 23-hour-stay basis and inpatients after major surgery and trauma are now discharged at a much earlier stage than in the past. However, prescription of opioids to be self-administered at home is not without risk. ⋯ Concerns about the potential for harm arising from prescription of opioids for ongoing acute pain management after discharge are relatively recent. However, at a time when serious problems resulting from the non-medical use of opioids have reached epidemic proportions in the community, all doctors must be aware of the potential risks and be able to identify and appropriately manage patients where there might be a risk of prolonged opioid use or misuse. Anaesthetists are ideally placed to exercise stewardship over the use of opioids, so that these drugs can maintain their rightful place in the post-discharge analgesic pharmacopoeia.
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Anaesth Intensive Care · Sep 2014
Inter-rater reliability of the ASA physical status classification in a sample of anaesthetists in Western Australia.
The American Society of Anesthesiologists (ASA) scale is a widely used six-point ordinal scale that allows anaesthetists to assign a risk score to each patient scheduled for anaesthesia. Earlier studies of inter-rater reliability in assigning ASA physical status classifications to a standard set of patient descriptions have shown modest agreement. We surveyed 401 anaesthetists practising in Western Australia using descriptions of clinical history, physical examination and investigation results of ten hypothetical adult patients, pre-designed by other researchers, to have ASA class ranging 1 through 5. ⋯ Correctly identifying ASA class was not related to age, level of training, sex or training region. We found only fair agreement among anaesthetists in assigning ASA class to ten fictitious patients, which was no better than that observed in earlier studies. Further, the range of scores assigned to standard patients' histories by anaesthetists supports earlier concerns about the robustness of this classification.
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Anaesth Intensive Care · Sep 2014
Difficult airway equipment: a survey of standards across metropolitan Perth.
The importance of appropriate equipment to manage the difficult airway has been highlighted by the publication of the Australian and New Zealand College of Anaesthetists (ANZCA) guidelines in 2012. We set out to audit compliance with these guidelines in all public and private sites providing general anaesthesia in metropolitan Perth. Public and private health care websites identified 39 sites of which 37 were studied. ⋯ Capnography was available in 76% of post anaesthesia care units and used regularly in 27%. Adherence to the ANZCA guidelines regarding the DDAC could be improved. Standardised equipment across a metropolitan region would be of value in the management of the difficult airway.