Anaesthesia and intensive care
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A knowledge of pharmacokinetic principles is essential to understand dosage modification for drugs used in patients in renal failure. Dosage modification is indicated either where drugs have a low therapeutic index, or where renal mechanisms play a major role in drug elimination. ⋯ In addition to effects on drug elimination, renal failure may also alter drug absorption, distribution, protein binding and metabolism. Dialysis regimens, by eliminating drugs to a greater or lesser degree, have implications for drug therapy.
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Anaesth Intensive Care · Aug 1983
Case ReportsAnaesthetic implications of the mucopolysaccharidoses: a fifteen-year experience in a children's hospital.
Patients suffering from the mucopolysaccharidoses, most commonly Hurler's syndrome, present special problems in anaesthesia. A retrospective review of the anaesthetic management of such patients over fifteen years revealed a high incidence of airway problems. Two case histories illustrating these difficulties are presented.
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Anaesth Intensive Care · Aug 1983
Comparative StudyThe making of an anesthesiologist: a review of the American scene.
Many anaesthetists practising in Australia and New Zealand realise that differences exist in the training of their counterparts in the United States. This review attempts to highlight the differences observed by two anaesthetists who have been involved in both systems. Aspects of the American Board of Anesthesiology examination are discussed from this viewpoint.