The Clinical journal of pain
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To examine the United States Food and Drug Administration's (FDA) standards for reviews of the scientific basis for efficacy claims for newly approved oral analgesics. ⋯ The requirements for approval of new analgesics in the United States encourage the pharmaceutical industry to perform efficacy studies using stylized designs in dental and nondental surgical pain. Studies of the efficacy of new analgesics in other common clinical settings are rarely or never included in development programs.
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Comparative Study Clinical Trial
Long-term peripheral nerve stimulation for painful nerve injuries.
Although peripheral nerve stimulation (PNS) has been used in the treatment of pain since 1965, only a few follow-up studies have been published. The aim of the present retrospective study was to carefully assess the long-term efficacy and safety of PNS in the treatment of painful nerve injuries. ⋯ PNS can produce good pain relief in the majority of carefully selected patients suffering from isolated painful neuropathies.
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Letter Comparative Study Clinical Trial
The intravenous administration of ketoprofene: a suitable alternative for acute postoperative pain management in developing countries.
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Letter Comparative Study Clinical Trial
Levetiracetam as migraine prophylaxis.