The Clinical journal of pain
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Randomized Controlled Trial
8% Lidocaine pump spray relieves pain associated with peripheral blood flow disorders.
It is often difficult to reduce pain associated with peripheral blood flow disorders (PBFD) using standard analgesics. We assessed the analgesic effects of a metered-dose 8% lidocaine in patients with PBFD. ⋯ A metered-dose 8% lidocaine pump spray produced prompt analgesia in patients with PBFD-related pain without severe side effects.
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Randomized Controlled Trial
The pain quality response profile of oxymorphone extended release in the treatment of low back pain.
In controlled trials of analgesics, the primary outcome variable is most often a measure of global pain intensity. However, because pain is associated with a variety of pain sensations, the effects of analgesic treatments on different sensations could go undetected if specific pain qualities are not assessed. This study sought to evaluate the utility of assessing the multiple components of non-neuropathic pain in an analgesic clinical trial. ⋯ The results indicate that oxymorphone ER has different effects on different pain qualities of low back pain. The responsivity of the PQAS items and scales to the results of treatment with an effective and generally well-tolerated dose of an analgesic, and the ability of the PQAS items and scales to discriminate between an active analgesic and placebo, support their validity as outcome measures. The findings support the utility of using pain descriptor measures for (1) identifying the effects of pain treatments on different pain qualities and (2) targeting pain treatments to those patients who experience certain types of pain.
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Controlled Clinical Trial
Capsaicin or menthol sensitization induces quantitative but no qualitative changes to thermal and mechanical pain thresholds.
To analyze whether sensitization procedures employed in experimental human pain models introduce additional components to pain measurements resulting in a different kind of pain or whether they are limited to quantitative changes resulting in the same pain at higher intensity. ⋯ The main effect of sensitization by capsaicin or menthol application is a quantitative decrease in thermal and mechanical pain threshold with the methodologic benefit of decreasing the incidence of censored data. A qualitative change in pain thresholds by sensitization is not supported by the present statistical analysis at level of primary hyperalgesia.
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To evaluate the psychometric properties of 4 measures of acute pain in youth with sickle cell disease (SCD) during a medical procedure. ⋯ Criterion and convergent validity were demonstrated for child-report, parent-report, and observable pain behaviors. These measures seem to tap into distinct, yet overlapping aspects of the pain experience. Assessment of acute procedural pain responses in SCD requires evaluation of preprocedural pain due to the frequent presence of low-level, baseline pain.
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Opioids have been used for medicinal and analgesic purposes for centuries. However, their negative effects on the endocrine system, which have been known for some times, are barely discussed in modern medicine. Therefore, we conducted a systematic review of the impact of opioids on the endocrine system. ⋯ Opioid-induced hypogonadism seems to be a common complication of therapeutic or illicit opioid use. Patients on long-term opioid therapy should be prospectively monitored, and in cases of opioid-induced hypogonadism, we recommend nonopioid pain management, opioid rotation, or sex hormone supplementation after careful consideration of the risks and benefits.