The Clinical journal of pain
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Randomized Controlled Trial
Effect of postoperative analgesia on energy metabolism and role of cyclooxygenase-2 inhibitors for postoperative pain management after abdominal surgery in adults.
It is questionable whether the stress response to surgery is necessary. The objective of this study was to evaluate the effectiveness of postoperative analgesia on energy metabolism and compare cyclooxygenase-2 selective inhibitor with tramadol in postoperative pain management after major abdominal surgery. ⋯ These results confirm that sufficient postoperative analgesia may be efficient to reduce some of the stress responses to operative trauma. In addition, intravenous parecoxib (40 mg bid) followed by oral celecoxib (0.2 g bid) is as effective as intravenous tramadol (0.1 g tid) with continued oral tramadol (0.1 g tid) after major abdominal surgery.
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Randomized Controlled Trial
Specificity and time-course of attentional bias in chronic headache: a visual-probe investigation.
The specificity and time-course of attentional bias in chronic headache were investigated. Individuals with chronic headache, compared with healthy controls, were hypothesized to show significant attentional bias towards disorder-relevant headache-related images. ⋯ Individuals with chronic headache demonstrate attentional bias towards pain information, which is most prominently shown towards stimuli relevant to their specific disorder. Biases are also more pronounced at longer stimuli presentation times associated with maintained attention. Future research should investigate the clinical implications of attentional bias in chronic headache, and further explore the benefits of attentional bias modification upon patient functioning.
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Randomized Controlled Trial
Allodynia in migraine: clinical observation and role of prophylactic therapy.
There is no study on the role of prophylactic therapy on allodynia in patients with migraine. We report the predictors of allodynia in migraine and the effect of divalproate or amitriptyline in alleviating allodynia. ⋯ 71.4% migraineurs had allodynia that was related to the duration, severity, frequency of migraine, and female gender. Divalproate and amitriptyline were equally effective in relieving allodynia.
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Randomized Controlled Trial
Alternating-frequency TENS effects on experimental pain in healthy human participants: a randomized placebo-controlled trial.
Transcutaneous electrical nerve stimulation (TENS) is a modality commonly used in pain management. ⋯ The alternating-frequency setting does not result in large hypoalgesic effects such as those previously reported using fixed-frequency TENS.
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Randomized Controlled Trial
Somatosensory sensitivity in patients with persistent idiopathic orofacial pain is associated with pain relief from hypnosis and relaxation.
In a recent study hypnosis has been found to relieve persistent idiopathic orofacial pain. Quantitative sensory testing (QST) is widely used to evaluate somatosensory sensitivity, which has been suggested as a possible predictor of management outcome. The objectives of this study were to examine: (1) possible associations between clinical pain relief and baseline somatosensory sensitivity and (2) the effect of hypnosis management on QST parameters. ⋯ High pain sensitivity at baseline may predict poor pain management outcome. In addition, despite clear clinical pain relief, hypnosis did not significantly or specifically influence somatosensory sensitivity. Future studies should further explore QST measures as possible predictors of different management response in orofacial pain conditions.