The Clinical journal of pain
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Randomized Controlled Trial
Evaluation of multiday analgesia with etoricoxib in a double-blind, randomized controlled trial using the postoperative third-molar extraction dental pain model.
To evaluate the analgesic effects of etoricoxib and comparator agents on the second and third days after oral surgery. ⋯ Pain control was most favorable for the etoricoxib doses and ibuprofen. Global Assessments of Study Medication continued to differentiate the treatments and demonstrated greater efficacy for etoricoxib on Days 2 and 3 compared with placebo and A/C (NCT00694369).
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Randomized Controlled Trial
Cognitive testing and revision of the pain quality assessment scale.
To revise the Pain Quality Assessment Scale (PQAS) using feedback from patients to further increase its validity. ⋯ testing can be used to improve the understandability of pain measures. The results of cognitive testing with the PQAS indicated that much of the content of the original instructions and items were understandable as written, but that minor changes could be made to make them even clearer to patients with chronic pain. The changes made resulted in a revised PQAS that is more understandable and may therefore be even more useful than with the original PQAS.
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Randomized Controlled Trial Multicenter Study
Gastroretentive gabapentin (G-GR) formulation reduces intensity of pain associated with postherpetic neuralgia (PHN).
To evaluate the safety and efficacy of a once-daily gastroretentive formulation of gabapentin (G-GR; 1800 mg). ⋯ Once-daily G-GR 1800 mg was effective and well tolerated for the relief of pain in patients with postherpetic neuralgia.
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Randomized Controlled Trial Clinical Trial
Research to encourage exercise for fibromyalgia (REEF): use of motivational interviewing, outcomes from a randomized-controlled trial.
Regular exercise is associated with important benefits in patients with fibromyalgia (FM). Unfortunately, long-term maintenance of exercise after a structured program is rare. The present study tested the efficacy of Motivational Interviewing (MI) to promote exercise and improve symptoms in patients with FM. ⋯ Despite a lack of benefits on long-term outcome, MI seems to have short-term benefits with respect to self-report physical activity and clinical outcomes. This is the first study in FM that explicitly addresses exercise maintenance as a primary aim.
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Randomized Controlled Trial
OnabotulinumtoxinA improves tactile and mechanical pain perception in painful diabetic polyneuropathy.
Diabetic neuropathic pain may be relieved by onabotulinumtoxinA (BoNT/A). However, whether BoNT/A changes sensory perception in neuropathic patients remains unknown. This study used a double-blind crossover design to explore the possible effect of BoNT/A on sensory perception. ⋯ BoNT/A may improve tactile and mechanical pain perception in painful diabetic polyneuropathy. The beneficial effects of BoNT/A deserves further study to elucidate the exact mechanism and potential for preventing insensate injuries.