The Clinical journal of pain
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Randomized Controlled Trial Clinical Trial
Efficacy of microcurrent therapy in the treatment of chronic nonspecific back pain: a pilot study.
Microcurrent therapy (MCT) is a novel treatment for pain syndromes. The MCT patch is hypothesized to produce stimuli that promote tissue healing by facilitating physiologic currents. Solid evidence from randomized clinical trials is lacking. To evaluate the efficacy of MCT in treating aspecific, chronic low-back pain, we conducted a double-blind, randomized, crossover, pilot trial. ⋯ A positive trend in MCT use for aspecific, chronic low-back pain is reported. Further investigations are required to evaluate the significance and relevance of this.
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Randomized Controlled Trial
A randomized controlled trial of vapocoolant for pediatric immunization distress relief.
The purpose of this study was to evaluate the effectiveness of vapocoolant for preschoolers' immunization injection pain relief. ⋯ This study revealed that vapocoolant is not an effective pain management intervention for children's intramuscular injections.
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Randomized Controlled Trial Multicenter Study
A 1-year safety and efficacy study of duloxetine in patients with fibromyalgia.
Evaluate the efficacy and safety of duloxetine at doses up to 120 mg once daily in patients with fibromyalgia. ⋯ The profile of duloxetine for the long-term treatment of fibromyalgia was consistent with that seen in other indications for which the drug is currently marketed.
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Randomized Controlled Trial Multicenter Study
Efficacy and safety of lacosamide in diabetic neuropathic pain: an 18-week double-blind placebo-controlled trial of fixed-dose regimens.
The aims of this multicenter, randomized, placebo-controlled, double-blind trial were to confirm the efficacy of lacosamide at a daily dose of 400 mg/d and to explore the efficacy, safety, and tolerability of lacosamide 200 mg/d and 600 mg/d in the treatment of painful diabetic neuropathy. ⋯ Safety and efficacy analyses indicated that lacosamide 400 mg/d provided an optimal balance between efficacy and side effects in patients with painful diabetic neuropathy.
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Randomized Controlled Trial
Applicability of press needles to a double-blind trial: a randomized, double-blind, placebo-controlled trial.
Owing to a lack of a suitable needle procedure, it has been impossible to evaluate the efficacy of acupuncture in clinical studies using double-blind testing. We evaluated the applicability of a new kind of press needle (Pyonex) to a double-blind trial by comparing the press needle with a placebo (lacking the needle element). ⋯ The participants could not distinguish between the press needle and a placebo, and the data from the press needle group suggested a specific influence on patients with LBP. These findings imply that the press needle and a placebo provide an effective means of realizing a double-blind setting for clinical studies of acupuncture.