The Clinical journal of pain
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Randomized Controlled Trial Multicenter Study
Making pain assessment more accessible to children and parents: can greater involvement improve the quality of care?
To determine whether nursing and parental pain assessment documentation and analgesia administration increased with the use of a temporary tattoo of a pain intensity scale (TTPS) compared with a paper version of the pain scale (PPS). To document any adverse skin reactions from the use of the TTPS and to assess the feasibility and acceptability of the PPS and TTPS for use as postoperative pain assessment tools in the home and clinical setting. ⋯ The TTPS is a new method to engage children in pain assessment, which may have positive effects on the quality of postoperative pain assessment and management in hospital and home settings. Larger trials are needed to determine the effectiveness of the TTPS across all pediatric settings and for children with nonsurgical and also surgical pain. The findings from these pilot trials provide useful information for design and power estimation for further research in inpatient and home settings.
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Randomized Controlled Trial Comparative Study Clinical Trial
A randomized, double-blind, placebo-controlled pilot study of IV morphine-6-glucuronide for postoperative pain relief after knee replacement surgery.
To determine the dose-response effect of intravenous morphine-6-glucuronide (M6G) on acute postoperative pain. ⋯ The analgesic effect of M6G in postoperative pain was demonstrated with 30 mg/70 kg M6G superior to placebo. At this dose, M6G has a long duration of action as determined by a reduction in the use of morphine PCA over 12 and 24 hours.
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Randomized Controlled Trial Comparative Study Clinical Trial
Preincisional subcutaneous infiltration of ketamine suppresses postoperative pain after circumcision surgery.
N-methyl-D-aspartate and other glutamate receptors have been shown to present on the peripheral axons of primary afferents, and peripheral injection of N-methyl-D-aspartate-receptor antagonists can suppress hyperalgesia and allodynia. Thus, this study examined postoperative analgesic and adverse effects of local ketamine administered postoperatively. ⋯ We conclude that preincisional subcutaneous ketamine infiltration can suppress postoperative pain after the circumcision surgery.
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Randomized Controlled Trial Comparative Study Clinical Trial
The effect of intra-articular injection of ultracain in the temporomandibular joint in patients with preauricular pain: a randomized prospective double-blind placebo-controlled crossover study.
To evaluate the distinguishing ability of intra-articular anesthesia from placebo in orofacial pain patients with pain located in the temporomandibular joint (TMJ) region, aiming at a validation of intra-articular anesthesia injection as a diagnostic test of pain in the TMJ region. ⋯ TMJ injection with local anesthesia leads to the decrease of pain in patients with preauricular pain. To establish the source of pain, injection of a local anesthetic in the TMJ may be used as a diagnostic tool. However, the results of diagnostic injections should still be interpreted cautiously.
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Randomized Controlled Trial Multicenter Study
Lacosamide in painful diabetic peripheral neuropathy: a phase 2 double-blind placebo-controlled study.
Peripheral diabetic neuropathy affects between 20% and 45% of patients with diabetes. ⋯ Lacosamide seems to attenuate pain in diabetic neuropathy in doses up to 400 mg/d and improves quality of life issues.