The Journal of international medical research
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Randomized Controlled Trial
Opioid sparing effect and safety of nefopam in patient controlled analgesia after laparotomy: A randomized, double blind study.
A double-blind randomised study to evaluate the opioid sparing effect and safety of nefopam when administered via intravenous patient controlled analgesia (PCA) with fentanyl. ⋯ Intravenous PCA using nefopam + fentanyl following laparotomy has an opioid sparing effect and is associated with a low incidence of some of the typical opioid related adverse events.
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Randomized Controlled Trial Comparative Study
Comparison of effects of intravenous midazolam and ketamine on emergence agitation in children: Randomized controlled trial.
A prospective, double-blind, randomized controlled trial to compare the effect of preoperative midazolam or ketamine on the incidence of emergence agitation (EA) following sevoflurane anaesthesia in children. ⋯ Premedication with ketamine is more effective than midazolam in preventing EA during the early emergence period after sevoflurane anaesthesia in children.
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Randomized Controlled Trial
Efficacy of intrathecal morphine for postoperative pain management following open nephrectomy.
To evaluate the efficacy and safety of intrathecal morphine (ITM) for postoperative pain control in patients with renal cell carcinoma undergoing open nephrectomy. ⋯ ITM was associated with greater analgesia without serious complications in patients undergoing open nephrectomy.
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Randomized Controlled Trial
Efficacy of early intravenous bolus oxycodone or fentanyl in emergence from general anaesthesia and postoperative analgesia following laparoscopic cholecystectomy: A randomized trial.
To compare prospectively the efficacy of early intravenous bolus of oxycodone or fentanyl in providing analgesia at emergence from general anaesthesia following laparoscopic cholecystectomy. ⋯ Oxycodone relieves immediate postoperative pain significantly better than fentanyl, and is not associated with an increase in side-effects in patients undergoing laparoscopic cholecystectomy.
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Randomized Controlled Trial
The effect of extraction angle on endotracheal tube extubation force: Simulation and randomized clinical trial.
To evaluate the extraction force generated at different extubation angles using a manikin simulation and a randomized clinical trial. ⋯ Findings in a manikin simulation were confirmed by those of a randomized clinical trial, where extubation at 60° required less force than 90°, and was accompanied by less SBP elevation. Extubation at 60° is less invasive than extubation at 90°.