The Journal of international medical research
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Randomized Controlled Trial Clinical Trial
Analgesic effect of aspirin, mefenamic acid and their combination in post-operative oral surgery pain.
A double-blind randomized single dose study of the analgesic effects of 650 mg aspirin, 250 mg mefenamic acid, the combination of 650 mg aspirin and 250 mg mefenamic acid and placebo on 120 patients with pain following oral surgery was conducted. Patients evaluated their pain intensity and extent of pain relief at 1, 2, 3 and 4 h after drug administration. For most parameters, including the sum of the pain intensity differences and the sum of the hourly pain relief scores, each of the drugs was more effective than placebo. Aspirin-mefenamic acid in combination was more effective than both drugs alone, and aspirin and mefenamic acid alone were equally effective for most of the analgesic variables.
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Comparative Study Clinical Trial Controlled Clinical Trial
Tizanidine and ibuprofen in acute low-back pain: results of a double-blind multicentre study in general practice.
This study reports on 105 patients with acute low-back pain given tizanidine (4 mg three times daily) plus ibuprofen (400 mg three times daily) or placebo plus ibuprofen (400 mg three times daily). Patients assessed their pain using visual analogue scales in a daily diary and the doctor assessed their condition at baseline and on days 3 and 7. Both groups were treated effectively, but earlier improvement occurred in patients given tizanidine/ibuprofen, particularly regarding pain at night and at rest. ⋯ More patients given tizanidine/ibuprofen suffered drowsiness and other central nervous system effects (P = 0.025). In patients with severe acute low-back pain, however, some sedation and bed rest is advantageous. This study shows that tizanidine/ibuprofen is more effective in the treatment of moderate or severe acute low-back pain than placebo and ibuprofen alone.
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This report describes a consensus on current asthma management in the UK, indicates areas of clinical concern and provides a rationale for improved therapy.
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Clinical Trial Controlled Clinical Trial
Analgesic efficacy of paracetamol/codeine and paracetamol/dextropropoxyphene in pain after episiotomy and ruptures in connection with childbirth.
Pain after episiotomy and/or perineal/vaginal rupture in childbirth is severe in many patients and in most cases it can be treated with oral analgesics. In this trial the efficacy and side-effect profile of two combination analgesics, paracetamol/codeine and paracetamol/dextropropoxyphene hydrochloride, were compared in post-partum pain after episiotomy and/or rupture of the perineum. Eighty-five patients were analysed for efficacy and 96 were included in an analysis of side-effects. Paracetamol/codeine was shown to give faster and more efficient pain relief while not causing constipation or other troublesome side-effects.
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Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical Trial
Comparison of a modified hydrocortisone/urea cream and betamethasone valerate cream in the treatment of dry eczema.
A half-sided, single-blind, comparative study of a new modified formulation of 1% hydrocortisone/10% urea and 0.1% betamethasone valerate cream in the treatment of dry eczema showed that the two products were equally effective at the end of 1, 2 and 3 weeks of treatment in terms of efficacy and speed of action. No statistically significant differences could be detected between either preparation in any of the trial's measures (i.e. overall severity score, dryness/scaling, erythema, papules, itching, excoriation or lichenification) at any of the weekly assessments. The incidence of side-effects was the same with both treatments and patients' preference was equally divided between the two creams.