Current medical research and opinion
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Comparative Study Clinical Trial
Utilization of duloxetine and celecoxib in osteoarthritis patients.
To describe utilization patterns of duloxetine and celecoxib and subsequent opioid use among patients with osteoarthritis. ⋯ Osteoarthritis patients initiating duloxetine had better compliance and a lower likelihood of opioid utilization than those initiating celecoxib. Study limitations included lack of information on reasons for medication initiation and discontinuation, severity of disease symptoms, and use of over-the-counter medications.
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Comparative Study
Real-world comparative outcomes of US type 2 diabetes patients initiating analog basal insulin therapy.
To evaluate outcomes in insulin-naive patients with type 2 diabetes mellitus (T2DM) who initiated insulin glargine or insulin detemir. ⋯ Results from this real-world EMR analysis suggest that among T2DM patients, initiating insulin treatment with insulin glargine may be associated with better treatment persistence and glycemic control, with similar prevalence of hypoglycemia and weight change, compared with initiating with insulin detemir. This study is limited by the retrospective nature of the data collection using EMRs and inability to confirm accuracy and completeness of data by secondary chart review.