Current medical research and opinion
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Observational Study
Safety of purified Vero cell rabies vaccine manufactured in Pakistan: A comparative analysis of intradermal and intramuscular routes.
Rabies vaccines are conventionally given via the intramuscular (IM) route; however, switching the route of administration from IM to intradermal (ID) without affecting efficacy can be advantageous in terms of cost, dosing, and time. Hence, it is indispensable to evaluate its safety along different routes. This study was carried out to ascertain the frequency of adverse drug events (ADEs) and associated factors, as well as to compare safety based on the IM and ID routes. ⋯ Half of the study participants reported ADEs. Almost similar proportions of local and systemic effects were observed. Likewise, the ADEs recorded were comparable for both routes. PVRV carries very low safety concerns with either route for administration.
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This commentary takes note of the existence of "tortured phrases" (i.e. unspecific jargon or confusing alternative phrases), as indexed in the Tortured Phrases Detector of the Problematic Paper Screener (PPS) (sourced on January 10, 2023) in 213 preprints, 13 of which are related to COVID-19. Select "tortured phrases" in 11 preprints are highlighted, to offer readers an appreciation of this phenomenon. ⋯ This commentary is thus only a spring-board to introduce this linguistic phenomenon and to encourage interested academics to explore more cases, the practical implications of their existence, and even the weaknesses and strengths of PPS. Caution is needed about excessive extrapolation of the existence of "tortured phrases", so as not to automatically associate them with ethical infractions or misconduct.