Journal of critical care
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Journal of critical care · Feb 2025
Optimizing fosfomycin dosing regimens in critically ill patients with and without continuous renal replacement therapy.
To define the optimal fosfomycin dosing regimens for drug-resistant gram-negative bacteria in critically ill patients and those receiving continuous renal replacement therapy (CRRT) via Monte Carlo simulations. ⋯ Dosing regimens for bacteria with high MICs as 64 mg/L in these patients were 18-24 g/day. Dose adjustments were required in those undergoing CRRT. Clinical validation is strongly needed.
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Journal of critical care · Feb 2025
Observational StudyTransesophageal echocardiography and intracerebral pressure (ICP) in neurocritical care patients - An observational study.
Transesophageal echocardiography (TEE) may cause an increase in intracerebral pressure (ICP). Data are currently lacking. ⋯ This study is the first to investigate the effect of transesophageal echocardiography on ICP and CPP. Our data demonstrated a temporary increase in ICP during TEE probably caused by lateral positioning the patients. For patients at risk with critically elevated ICP values, TEE should only be performed in the supine position.
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Journal of critical care · Feb 2025
Multicenter Study Comparative Study Observational StudyA tidal volume of 7 mL/kg PBW or higher may be safe for COVID-19 patients.
The novel coronavirus disease (COVID-19) has revived the debate on the optimal tidal volume during acute respiratory distress syndrome (ARDS). Some experts recommend 6 mL/kg of predicted body weight (PBW) for all patients, while others suggest 7-9 mL/kg PBW for those with compliance >50 mL/cmH2O. We investigated whether a tidal volume ≥ 7 ml/kg PBW may be safe in COVID-19 patients, particularly those with compliance >50 mL/cmH2O. ⋯ A tidal volume ≥ 7 (up to 9) mL/kg PBW was associated with lower ICU mortality in these COVID-19 patients, including those with compliance <40 mL/cmH2O. This finding should be interpreted cautiously due to the retrospective study design.