Journal of critical care
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Journal of critical care · Jun 1994
Hemodynamic effects following injection of venom from the scorpion Leiurus quinquestriatus.
The present study tested the hypothesis that scorpion sting induces left ventricular (LV) hypokinesia and myocardial ischemia shortly after injection due to reduction of coronary blood flow (CBF) and increased oxygen demand. ⋯ Myocardial ischemia does not occur in this dog model immediately following administration of scorpion venom. There are significant peripheral circulatory effects of the venom, which account for many of the hemodynamic changes.
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Journal of critical care · Jun 1994
Effect of inhibition of nitric oxide release on the diaphragmatic oxygen delivery-consumption relationship.
In the vascularly isolated resting and contracting (3 Hz) canine hemidiaphragm, the hypothesis that nitric oxide (NO) is an important regulator of diaphragmatic O2 extraction was tested. ⋯ These results indicate that NO release is an important modulator of the tone of diaphragmatic resistance vessels, but it does not appear to regulate the processes by which O2 extraction is enhanced to compensate for decreased O2 delivery.