Journal of critical care
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HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded during normoxic conditions. In hypoxic conditions, it persists and is active. ⋯ In this review, the function of HIF-1 is examined, as well as its clinical significance with regard to trauma and critical care. Using this information, we then identify potential points of treatment and intervention.
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Journal of critical care · Dec 2017
Multicenter StudyA multifactor model for predicting mortality in critically ill patients: A multicenter prospective cohort study.
The objective of this study was to develop a model using a combination of routine clinical variables to predict mortality in critically ill patients. ⋯ The developed multifactor model can be used to effectively predict mortality in critically ill patients at ICU admission.
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Journal of critical care · Dec 2017
ReviewCritical care of tropical disease in low income countries: Report from the Task Force on Tropical Diseases by the World Federation of Societies of Intensive and Critical Care Medicine.
Tropical disease results in a great burden of critical illness. The same life-saving and supportive therapies to maintain vital organ functions that comprise critical care are required by these patients as for all other diseases. ⋯ Improving critical care in low income countries requires a focus on hospital design, training, triage, monitoring & treatment modifications, the basic principles of critical care, hygiene and the involvement of multi-disciplinary teams. As a large proportion of critical illness from tropical disease is in low income countries, the impact and reductions in mortality rates of improved critical care in such settings could be substantial.
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Journal of critical care · Dec 2017
ReviewVascular air embolism: A silent hazard to patient safety.
To narratively review published information on prevention, detection, pathophysiology, and appropriate treatment of vascular air embolism (VAE). ⋯ VAE is an important and underappreciated complication of surgery, anesthesia and medical procedures.
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Journal of critical care · Dec 2017
Observational StudyPatterns of C-reactive protein ratio predicts outcomes in healthcare-associated pneumonia in critically ill patients with cancer.
Describe the patterns of C-reactive protein relative changes in response to antibiotic therapy in critically ill cancer patients with healthcare-associated pneumonia (HCAP) and its ability to predict outcome. ⋯ CRP-ratio was useful in the early prediction of poor outcomes in cancer patients with HCAP.