Journal of critical care
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Journal of critical care · Oct 2018
Observational StudyToll-like receptor 2, 4 and 9 polymorphisms and their association with ICU-acquired infections in Central Greece.
To test the potential of four common Toll-like receptor (TLR) polymorphisms to predispose to specific intensive care unit (ICU)-acquired infections and affect outcomes in a Greek ICU. ⋯ Common TLR-signaling polymorphisms might be implicated in the clinical phenotype of ICU-acquired infections in Central Greece. The possible impact of TLR4 polymorphisms on enhanced susceptibility towards Gram-negative MDR-infections in defined critical-disease states warrants further investigation. Trial Registration Clinical Trials.gov identifier: NCT00932243.
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Journal of critical care · Oct 2018
Combination of hemoglobin and low-flow duration can predict neurological outcome in the initial phase of out-of-hospital cardiac arrest.
To predict neurological outcome following out-of-hospital cardiac arrest (OHCA) using a combination of hemoglobin (Hb) and low-flow duration (LFD). ⋯ Patients with FNR following OHCA had high Hb levels and short LFDs; the Hb/LFD value significantly predicted FNR.
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Journal of critical care · Oct 2018
Association between the neutrophil-to-lymphocyte ratio and neurological outcomes in patients undergoing targeted temperature management after cardiac arrest.
This study aimed to elucidate the association between the neutrophil-to-lymphocyte ratio (NLR) and neurological outcomes in out-of-hospital cardiac arrest (OHCA) patients treated with targeted temperature management (TTM). ⋯ An NLR ≥ 6 at 72 h after the ROSC is associated with poor neurological outcomes at 6 months after CA.
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Journal of critical care · Oct 2018
The evolution of activated protein C plasma levels in septic shock and its association with mortality: A prospective observational study.
Septic shock is commonly associated with hemostatic abnormalities. The endothelium-activated serine protease activated protein C (APC) plays a pivotal role in limiting coagulation and possesses anti-apoptotic and anti-inflammatory properties. We hypothesized that APC levels correlate with established coagulation parameters and provide prognostic information in patients with septic shock. ⋯ APC levels are increased in patients with septic shock and are correlated with established markers of coagulation. Elevated APC levels on admission are an independent predictor of mortality.