Journal of critical care
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Journal of critical care · Feb 2018
ReviewOvercoming the Warburg Effect: Is it the key to survival in sepsis?
Sepsis is a leading cause of mortality in the U. S. and Europe. Sepsis and septic shock are the results of severe metabolic abnormalities following infection. ⋯ Although the initial pathways of cancer and sepsis may be different, the mechanisms which allow aerobic glycolysis to occur, even in the presence of oxygen, are similar. This review provides some evidence that reversing these steps reverses the Warburg Effect in model systems and some pathological consequences of this effect. Therefore, this implies that these steps might be modifiable in sepsis to reverse the Warburg Effect and possibly lead to better outcomes.
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Journal of critical care · Feb 2018
Observational StudyCirculating syndecan-1 predicts the development of disseminated intravascular coagulation in patients with sepsis.
One of the pathophysiological processes in sepsis is endothelial dysfunction, which leads to disseminated intravascular coagulation (DIC). Syndecan-1 is a major structural component of the endothelium and plays a key role in endothelial function. The purpose of this study was to assess the value of syndecan-1 as a predictive marker for DIC in sepsis. ⋯ Syndecan-1 levels were associated with not only the severity of illness and mortality but also DIC development in sepsis, suggesting that syndecan-1 could be a predictive marker of DIC.
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Journal of critical care · Feb 2018
Multicenter StudyPhysician attire in the intensive care unit in Japan influences visitors' perception of care.
The objective of this study is to evaluate the impact of physician attire and behavior on perceptions of care by ICU visitors in Japan. ⋯ Physician attire in the ICU affects perceptions of care. Implementation of attire guidelines which require clothing that does not meet visitor preferences should be accompanied by education programs.
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Journal of critical care · Feb 2018
Revisiting the prognostic value of monocyte chemotactic protein 1 and interleukin-6 in the sepsis-3 era.
Monocyte Chemotactic Protein 1 (MCP1) and latest sepsis-3 criteria are poorly represented within studies evaluating biomarkers in sepsis. Therefore, this study evaluates the prognostic value of MCP-1 compared to interleukin-6 (IL-6) in patients with sepsis and septic shock according to sepsis-3 criteria. ⋯ Both MCP-1 and IL-6 revealed prognostic value for short- and mid-term all-cause mortality in patients with sepsis and septic shock according to latest sepsis-3 definitions.
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Journal of critical care · Feb 2018
Multicenter StudyRisk of drug resistance in repeat gram-negative infections among patients with multiple hospitalizations.
Drug resistance in gram-negative bacterial hospital-acquired infections (GNB HAIs) has become ubiquitous in recent years. Patients who experience multiple hospitalizations are at high risk of developing repeat GNB HAIs. This study aims to evaluate the relationship between repeat GNB HAIs and antibiotic susceptibility patterns. ⋯ Prevention of repeat infections in high healthcare utilizers may be important in reducing drug resistance in this population.