Journal of critical care
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Journal of critical care · Aug 2021
Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome.
To measure the rate of recall of study participation and study attrition in survivors of acute respiratory distress syndrome(ARDS). ⋯ One in 4 ARDS survivors do not recall their participation in a clinical trial during hospitalization 3 months following hospital discharge, which did not influence 6-month attrition. However, more patients recall study participation if reconsent is obtained.
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Journal of critical care · Aug 2021
Common biomarkers of physiologic stress and associations with delirium in patients with intracerebral hemorrhage.
To examine associations between physiologic stress and delirium in the setting of a direct neurologic injury. ⋯ Stress-related biomarkers corresponding to multiple organ systems are associated with ICH-related delirium. Early NLR elevation may also predict delayed-onset delirium, potentially implicating systemic inflammation as a contributory delirium mechanism.
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Journal of critical care · Aug 2021
Timing of continuous renal replacement therapy in severe acute kidney injury patients with fluid overload: A retrospective cohort study.
We aimed to evaluate the association of early versus late initiation of Continuous renal replacement therapy (CRRT) with mortality in patients with fluid overload. ⋯ Early initiation of CRRT was independently associated with survival benefits in severe AKI patients with fluid overload.
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Journal of critical care · Aug 2021
High-dose CytoSorb hemoadsorption is associated with improved survival in patients with septic shock: A retrospective cohort study.
Hemoadsorption with CytoSorb® offers a possible therapeutic approach in septic shock, but modes of application and dosing are still undetermined. ⋯ The application of CytoSorb® seems to be effective in various conditions of septic shock. In a cohort of most severely ill patients the observed mortality was lower than predicted and decreased linearly with blood purification volumes inadvertently exceeding 6 l/kg BW. These results suggest that hemoadsorption might improve survival provided that the applied dose is high enough.
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Journal of critical care · Aug 2021
Anti-infectious decontamination strategies in Dutch intensive care units: A survey study on contemporary practice and heterogeneity.
Despite increasing evidence and updated national guidelines, practice of anti-infectious strategies appears to vary in the Netherlands. This study aimed to determine the variation of current practices of anti-infectious strategies in Dutch ICUs. ⋯ The proportion of Dutch ICUs applying SDD or SOD increased over time. Considerable heterogeneity in the regimens was reported. The impact of the observed differences within SDD and SOD practices on clinical outcome remains to be explored.