Journal of critical care
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Journal of critical care · Apr 2024
ReviewAn environmental scan of online resources for informal family caregivers of ICU survivors.
To collate a comprehensive repository of online resources for family caregivers of intensive care survivors to inform a recovery website and digital peer support programme. ⋯ This environmental scan identifies multiple resources addressing informational needs of family caregivers and highlights areas for resource development.
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Journal of critical care · Apr 2024
Multicenter StudyDevelopment and validation of a machine learning model to predict the use of renal replacement therapy in 14,374 patients with COVID-19.
To develop a model to predict the use of renal replacement therapy (RRT) in COVID-19 patients. ⋯ An early ML model using easily available clinical and laboratory data accurately predicted the use of RRT in critically ill patients with COVID-19. Our study demonstrates that using ML techniques is feasible to provide early prediction of use of RRT in COVID-19 patients.
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Journal of critical care · Apr 2024
Letter ReviewHeart involvement: A neglected manifestation of haemophagocytic syndrome associated with high mortality.
Secondary haemophagocytic lymphohistiocytosis (sHLH) proceeds from uncontrolled and inefficient immune activation leading to hyper-inflammation and multi-organ damage. sHLH proceeds from a wide panel of infectious, auto immune and malignant conditions and bears high mortality despite treatment. Literature on sHLH does not mention heart involvement. We sought to describe occurrence of reversible heart dysfunction in the setting of HLH in order to motivate larger prospective studies assessing the causality link between both conditions. ⋯ This leads us to hypothesize that heart involvement confers worse prognosis to HLH. Formal accountability of HLH in the occurrence of cardiac manifestations is difficult to establish given the numerous differential diagnoses but reversibility of myocardial dysfunction in 14 survivors and results of two necropsies supported it. These data, and the current knowledge on the pathophysiology of both HLH and heart failure lead us to suggest that such a link may exist.