Journal of critical care
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Journal of critical care · Mar 1998
ReviewParacrine regulation of cardiac myocytes in normal and septic heart.
A paracrine pathway for the regulation of cardiac contractile function by nonmuscle cells is documented in the heart. Coronary and endocardial endothelium release several diffusible agents, such as prostaglandins, endothelin-1, and nitric oxide, with an action on cardiac myocyte function. ⋯ In addition to cardiac myocytes, activated microvascular endothelial cells and cardiac endothelial cells may contribute to nitric oxide generation and, ultimately, to the depression of myocardial contractile activity during sepsis. This article reviews the local intercellular communication between cardiac myocytes and endothelial cells in the normal heart and discusses some of the mechanisms potentially claimed to depress heart function in sepsis.
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Journal of critical care · Mar 1997
ReviewTissue hypoxia: how to detect, how to correct, how to prevent? Third European Consensus Conference in Intensive Care Medicine. Organized by the Société de Réanimation de Langue Française, Cosponsored by the American Thoracic Society and the European Society of Intensive Care Medicine.
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Journal of critical care · Dec 1996
Editorial Comment ReviewCardiovascular derangement in septic shock and nitric oxide.