Journal of critical care
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Journal of critical care · Dec 1995
Local and systemic effects of endotoxin in contracting skeletal muscle.
This study was performed to determine the direct effect of endotoxin on force generation, O2 consumption and vascular resistance in contracting skeletal muscle. ⋯ Endotoxin must affect muscle force production by acting through intermediates such as cytokines, and the effect is not apparent in the first 60 minutes.
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Journal of critical care · Dec 1995
Multicenter Study Comparative Study Clinical TrialThe influence of clinical study design on cost-effectiveness projections for the treatment of gram-negative sepsis with human anti-endotoxin antibody.
This study was performed to compare the effect of entry criteria, patient population, and study design on outcome and projected cost-effectiveness of human anti-endotoxin antibody (HA-1A). ⋯ Extrapolating cost-effectiveness from RCT-derived analyses to open-label usage may yield widely inaccurate projections because of only small differences in patient population and the drug administration protocol.
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Although pyruvate supplementation enhances endurance in humans and increases cardiac output in dogs, its effects on cardiac and peripheral vascular function are not known. Thus, we assessed the cardiovascular effects of pyruvate infusion. ⋯ We conclude that pyruvate infusion in normal dogs induces venodilation but does not alter either cardiac contractility or arterial tone.