Pediatric hematology and oncology
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Pediatr Hematol Oncol · May 1997
ReviewAcademic pediatrics in the Emma Children's Hospital, Academic Medical Center in Amsterdam (The Netherlands).
In 1988 the Emma Children's Hospital and the department of pediatrics of the Academic Medical Center in Amsterdam (The Netherlands) merged. With the integration of the Emma Children's Hospital and the academic pediatric department, an academic children's hospital (ECH/ AMC) was established with all pediatric subspecialties including oncology, pediatric hematology/ hemostasis, and immunology. The research is organized in special research institutes. ⋯ Considerable effort is given to the care of patients with hemophilia and congenital clotting disorders. One of the special fields in immunology is the care for children infected with human immunodeficiency virus (HIV). The Emma Children's Hospital AMC participates in national and international programs for human immunodeficiency virus and AIDS research and immunological diseases, especially chronic granulomatous disease, in which an internationally appreciated know-how has been built up.
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The Manchester pediatric oncology unit is the third largest unit in the United Kingdom, with approximately 120 new referred cases per annum (10% of the U. K. total). Research activities include a gene therapy program, peripheral blood stem cell studies, the genetic epidemiology of childhood cancer, late-effects research (growth, body composition, pulmonary, quality of life), psychosocial studies, and clinical trial organization. ⋯ The unit contains the second largest children's hemophilia service in the United Kingdom, serving 200 patients with congenital blood disorders. Twenty-five bone marrow transplants are performed each year (allogeneic, unrelated donor, autologous, and peripheral stem cell) for malignant and nonmalignant disorders. These activities are closely related to local, national, and international research groups.
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Pediatr Hematol Oncol · Sep 1994
Review Case ReportsWilms' tumor with intracardiac extension: chemotherapy before surgery.
The article describes two Chinese boys ages 2 and 3 years with unilateral Wilms' tumors complicated by intracaval and intracardiac extension. In contrast to the previously recommended treatment with surgery followed by chemotherapy and radiation therapy, the children were managed primarily with combination chemotherapy before definitive operation. Reduction of tumor size on serial imaging was documented, and no viable tumor cells were found when the involved kidney and right atrium were explored. ⋯ Wilms' tumor presenting with extension into the inferior vena cava and right atrium is thus rare and renders the affected child with additional cardiovascular complications and operative risks. As a result of the uncommon occurrence, a consensus on management based on prospective study would be difficult. The present report and the literature are supportive of the use of preoperative chemotherapy in the initial management of advanced Wilms' tumor extending into the right atrium.