Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Randomized Controlled Trial Clinical Trial
Physostigmine increases the dose of propofol required to induce anaesthesia.
This prospective, randomized, double-blind study was performed to determine the effect of administration of physostigmine on the dose of propofol required to produce loss of consciousness. ⋯ Physostigmine pretreatment increases the dose of propofol required to produce loss of consciousness.
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Lack of financial information results in planning difficulties and may delay the introduction of simulator based education. We collected data from an existing simulation centre and describe a construction and operating budget to facilitate planning and construction for interested institutions. ⋯ Substantial resources are required for the construction of a simulation centre ($665,000) primarily use of capital equipment purchases. However, there is also a considerable operating cost per year ($167,250) which consists mostly of salary support.
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Randomized Controlled Trial Clinical Trial
Prophylactic oral dolasetron mesylate reduces nausea and vomiting after abdominal hysterectomy. The Canadian Dolasetron Study Group.
The incidence of postoperative nausea and vomiting (PONV) varies from 50% to 75% after gynaecological surgery under general anaesthesia. This study evaluates the dose-response relationships, safety, and efficacy of the new 5-HT3 antagonist, dolasetron mesylate, in the prevention of PONV in women undergoing total abdominal hysterectomy (TAH). ⋯ Prophylactic dolasetron (100 mg and 200 mg) reduces the incidence of PONV in patients having total abdominal hysterectomy.
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Randomized Controlled Trial Comparative Study Clinical Trial
Platelet aggregation is impaired during anaesthesia with sevoflurane but not with isoflurane.
Halothane suppresses platelet aggregation in vitro and ex vivo, and prolongs bleeding time. In a previous in vitro study we demonstrated that sevoflurane had a more suppressive effect on platelet aggregation than did halothane. The present study investigated whether the clinical use of sevoflurane affected platelet aggregation ex vivo. ⋯ Sevoflurane, but not isoflurane, alters platelet aggregation in the clinical situation, possibly by suppression of thromboxane A2 formation.
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Randomized Controlled Trial Clinical Trial
Arterial oxygenation during one lung ventilation.
To compare the effects of isoflurane and sevoflurane on arterial oxygenation and middle cerebral artery blood flow velocity during one lung ventilation. ⋯ In clinical practice, the selection of either isoflurane and sevoflurane for OLV was of no difference in terms of the arterial blood oxygenation. With both agents MCA blood flow velocity was maintained during OLV.