Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Propofol is thought to act on gamma-aminobutyric acid receptors, which have some role in pain transmission in the spinal cord. In this study, we examined the effects of intrathecal propofol on acute thermally- or inflammation-induced pain in rats. ⋯ Intrathecal administration of propofol had analgesic effects on inflammation-induced acute and facilitated pain but not on thermally-induced acute pain. Transient motor and sensory disturbance could not rule out the possibility of neurotoxicity.