Canadian journal of anaesthesia = Journal canadien d'anesthésie
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The purpose of this review is to summarize current knowledge of detailed biochemical evidence for the role of γ-aminobutyric acid type A receptors (GABA(A)-Rs) in the mechanisms of general anesthesia. ⋯ Establishment of a coherent and consistent structural model of the GABA(A)-R lends support to the conclusion that general anesthetics can modulate function by binding to appropriate domains on the protein. Genetic engineering of mice with mutation in some of these GABA(A)-R residues are insensitive to general anesthetics in vivo, suggesting that further analysis of these domains could lead to development of more potent and specific drugs.
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Letter Case Reports Comparative Study
Superior glottic views with the GlideScope® and Airtraq® laryngoscopes compared with an anterior commissure laryngoscope.
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Editorial Historical Article
Mechanisms of anesthesia: past, present, and a glimpse into the future.