Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Editorial Comment
"Seizing" the opportunity to understand antifibrinolytic drugs.
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Letter Case Reports Comparative Study
SLIPA™ may be more useful than other LMADs for difficult airway management.
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Randomized Controlled Trial Comparative Study
Use of a novel technique, solid phase microextraction, to measure tranexamic acid in patients undergoing cardiac surgery.
Solid phase microextraction (SPME) is a technique widely used and accepted in the field of food technology and in environmental and biological analyses. Despite its numerous advantages over older analytical methods, it has not been studied extensively in the medical sciences. Tranexamic acid (TXA) is currently the sole antifibrinolytic agent used during cardiac surgery involving the use of cardiopulmonary bypass (CPB). The current standard method of measuring TXA in plasma is based on plasma protein precipitation (PPP), but this analytical approach is time-consuming and not practical for routine use. The aim of the current study was to compare plasma TXA levels measured with the PPP method vs those acquired with the novel, highly efficient SPME technique. We also investigated the use of automated SPME with the aim of improving the technique so it could be used efficiently for measuring plasma TXA levels. ⋯ Solid phase microextraction is a relatively simple, rapid extraction technique that can facilitate future pharmacokinetic studies analyzing TXA drug concentrations and drug dosing in various clinical settings.
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Seizures after cardiac surgery are a serious complication. The antifibrinolytic agent tranexamic acid (TA), which has known proconvulsant properties, may be associated with postoperative seizures. We sought to determine the association between TA and other risk factors for seizures after cardiac surgery. ⋯ Our data suggest that multiple risk factors, including TA, are associated with seizures after cardiac surgery. Thus, the TA dose may be a readily modifiable risk factor for postoperative seizures.
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Letter Randomized Controlled Trial Comparative Study
[Single-use and reusable laryngoscope blades: a randomized controlled trial in elective surgery].