Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Statistical approaches have been developed to detect bias in individual trials, but guidance on how to detect systematic differences at a meta-analytical level is lacking. In this paper, we elucidate whether author bias can be detected in a cohort of randomized trials included in a meta-analysis. ⋯ When combining trial-level data to produce a pooled effect estimate, investigators must consider sources of potential bias. Our results suggest that systematic errors can be detected using meta-regression, although further research is needed to examine the sensitivity of this model. Systematic reviewers will benefit from the availability of methods to guard against the dissemination of results with the potential to mislead decision-making.
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Observational Study
Effect of cultural background and healthcare environment on postoperative opioid requirement.
The objective of this prospective observational study was to investigate the interactions between cultural background, healthcare environment, and postoperative pain experience. ⋯ These results suggest that postoperative pain behaviours and opioid requirement may be influenced by cultural background and healthcare environment in two populations of Chinese descent.
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Abstract
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Abstract
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Comment Letter
Comments on "Perioperative glucocorticoid stress dosing: a survey of anesthesiologists and general internists".
Abstract