Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Xenon has been shown to have positive neurologic effects in various pre-clinical models. This study systematically reviewed the randomized-controlled trials (RCTs) investigating neurologic and cognitive outcomes associated with the clinical use of xenon. ⋯ Despite promising pre-clinical results, the evidence for positive clinical neurologic and cognitive outcomes associated with xenon administration is modest. Nevertheless, there is some evidence to suggest that xenon may be associated with better neurologic outcomes compared with the standard of care therapy in certain specific clinical situations. More clinical trials are needed to determine any potential benefit linked to xenon administration.
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Comment Letter
In reply: Why goal-directed hemodynamic therapy is often ineffective and how can we try to improve the results.
Abstract
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Randomized Controlled Trial
Effect of preoperative warming on intraoperative hypothermia: a randomized-controlled trial.
The purpose of this study was to evaluate the effects of preoperative forced-air warming on intraoperative hypothermia. ⋯ A minimum of 30 min of preoperative forced-air convective warming decreased the overall intraoperative hypothermic exposure. While redistribution hypothermia still occurs despite pre- and intraoperative forced-air warming, their combined application results in greater preservation of intraoperative normothermia compared with intraoperative forced-air warming alone.
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Most cardiac surgery patients recover well; a substantial minority become critically ill after surgery. The epidemiology of critical illness after cardiac surgery is poorly described. We measured the association of prolonged critical illness with long-term survival and resource use after cardiac surgery. ⋯ Prolonged ICU LOS after cardiac surgery is associated with decreased 1-year survival and increased healthcare resource use.