Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Editorial Comment
The prescription opioid epidemic: a call to action for our profession.
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Review Meta Analysis Comparative Study
Efficacy of palonosetron for preventing postoperative nausea and vomiting: a systematic review and meta-analysis.
Palonosetron, a second-generation 5-hydroxytryptamine 3 receptor antagonist (5-HT3RA), has unique characteristics relative to first-generation 5-HT3RAs such as ondansetron. Nevertheless, it remains unclear if palonosetron is better than ondansetron for the prevention of nausea and vomiting during the first 24 hr after surgery and is thus the focus of this systematic review. ⋯ Palonosetron provides more effective prophylaxis of early PON, late PON, and late POV compared with ondansetron. Future studies are required to investigate the role of palonosetron during 24-72 hr following surgery.
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Randomized Controlled Trial Comparative Study
A randomized trial comparing axillary block versus targeted intracluster injection supraclavicular block for upper limb surgery.
This randomized trial aimed to validate a new method for brachial plexus blockade, i.e., targeted intracluster injection supraclavicular block (TII SCB), by comparing it with ultrasound-guided axillary block (AXB). We hypothesized that TII SCB would result in a shorter total anesthesia-related time. ⋯ Ultrasound-guided TII SCB provides a quicker onset and a shorter total anesthesia-related time than ultrasound-guided AXB.