Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Randomized Controlled Trial
Carbetocin at Cesarean delivery for labour arrest: a sequential allocation trial to determine the effective dose.
The aim of this study was to estimate the effective dose 90% (ED90) of carbetocin to provide adequate uterine tone at Cesarean delivery (CD) for labour arrest. ⋯ The ED90 of carbetocin at CD for labour arrest, as determined in our study, should be interpreted with caution since it may be underestimated. This dose is higher than the currently recommended dose of 100 µg at elective CD and should not be used routinely given the uncertainty regarding its efficacy and the high incidence of arrhythmias at higher doses. This trial was registered at ClinicalTrials.gov, number: NCT01725243.
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Review Meta Analysis
Postoperative recovery after anesthesia in morbidly obese patients: a systematic review and meta-analysis of randomized controlled trials.
Obese patients present a challenge to safe general anesthesia because of impaired cardiopulmonary physiology and increased risks of aspiration and acute upper airway obstruction. Since studies are lacking regarding the postoperative effects on recovery from general anesthesia in morbidly obese patients, we conducted a systematic review and meta-analysis of recovery outcomes in morbidly obese patients who had undergone general anesthesia. ⋯ Postoperative recovery was significantly faster after desflurane than after sevoflurane, isoflurane, or propofol anesthesia in obese patients. No clinically relevant differences were observed regarding PACU discharge time, incidence of PONV, or postoperative pain scores. The systematic review was registered with PROSPERO (CRD42014009480).
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Retraction Of Publication
Retraction Note to: Nicorandil accelerates recovery of neuromuscular block caused by vecuronium.
Retraction Note to: Can J Anesth 2001; 1: 28–33, DOI 10.1007/BF03019810. To our readers: Further to the Expression of Concern (http://www.springer.com/medicine/anesthesiology/journal/12630) posted online, it is with considerable regret that the Canadian Journal of Anesthesia hereby retracts the above-cited article by Dr. ⋯ Fujii in this study are exceedingly unlikely; and 2) the inability of Dr. Fujii’s institution to attest to the integrity of the study and/ or the data conducted under its auspices, as set out in the Joint Editors-in-Chief Request for Determination of April 9, 2012.
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Editorial Comment
The "Friday effect": Can epidemiology tell us when to operate?
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Ambulatory surgery is generally considered safe; however, as many as 3% of patients require unplanned acute postoperative care. The purpose of this study was to measure the impact of the day of the week of surgery on the outcomes of ambulatory surgery. ⋯ On a population level, there was a small effect of the day of the week of ambulatory surgery on outcomes; however, the clinical impact is likely not relevant. Certain surgical types may be more susceptible to a day of the week effect, but more research is needed to elucidate this notion.