Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Opioids have a narrow therapeutic index and have the potential to cause significant harm. Developmental and pharmacogenetic factors put children, and especially infants, at increased risk of complications. We performed a retrospective root cause analysis to identify the factors associated with critical incidents in children receiving opioid infusions in a tertiary care children's hospital. ⋯ The root causes of a range of critical incidents have been identified, and these have been used to generate recommendations for improving both patient safety and quality of analgesia for children receiving opioid infusions for acute pain management.
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Comparative Study Controlled Clinical Trial
Carbetocin at elective Cesarean delivery: a sequential allocation trial to determine the minimum effective dose.
The ED90 of carbetocin is approximately 15 mcg after elective cesarean section.
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Review Meta Analysis
Benzydamine hydrochloride on postoperative sore throat: a meta-analysis of randomized controlled trials.
Sore throat is a common postoperative complaint. The etiology of postoperative sore throat (POST) is considered the result of damage to airway mucosa after insertion of a laryngeal mask airway device or endotracheal tube. This paper proposes benzydamine hydrochloride (BH), a topical nonsteroidal anti-inflammatory drug (NSAID) with additional analgesic and local anesthetic properties, for POST prevention. ⋯ Our results indicate that the incidence of POST can be significantly reduced by prophylactic BH topical application to the oral cavity or airway devices. Further RCTs are required to overcome the limitations of heterogeneity and to determine the optimal dosage and application of BH for managing POST.