Critical care medicine
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Critical care medicine · Feb 2001
Editorial Comment ReviewThe hepatosplanchnic area and hyperlactatemia: A tale of two lactates.
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Critical care medicine · Feb 2001
Inhibition of hypoxic pulmonary vasoconstriction by carbon monoxide in dogs.
We tested the hypothesis that carbon monoxide might participate in the modulation of hypoxic pulmonary vasoconstriction (HPV) by prostacyclin (PGI2) and nitric oxide. ⋯ Endogenous carbon monoxide modulates canine HPV only in the absence of nitric oxide. The vasodilation mediated by nitric oxide, PGI2, or carbon monoxide is essentially distributed between proximal and distal sites proportionally to the degree of constriction produced during hypoxia.
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Critical care medicine · Feb 2001
Effect of NaHCO3 on cardiac energy metabolism and contractile function during hypoxemia.
To examine the impact of administration of NaHCO3 on contractility and energy metabolism of the myocardium during hypoxemia. ⋯ The response of the myocardium to hypoxia is to decrease its mechanical work and metabolic demand. The infusion of NaHCO3 did not enhance myocardial contractile function or flux in glycolysis during hypoxia. We speculate that this diminished mechanical work and metabolic demand may represent an adaptive response to preserve cellular integrity until oxygen delivery is restored.